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InterPro: IPR013846 mRNA capping enzyme, C-terminal

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UniProtKB

Matches:

178 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR013846 mRNA_cap_enzyme_C

Secondary

IPR001339

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF03919	mRNA_cap_C	178
Signatures in BioMart

InterPro Relationships Help

Found in

IPR017074 mRNA capping enzyme, bifunctional
IPR017075 mRNA capping enzyme, alpha subunit

Contains

IPR012340 Nucleic acid-binding, OB-fold

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found at the C terminus of the mRNA capping enzyme. The mRNA capping enzyme in yeasts is composed of two separate chains: alpha a mRNA guanyltransferase and beta an RNA 5'-triphosphate. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes [1]. Binding of the enzyme to nucleotides is specific to the GMP moiety of GTP. The viral mRNA capping enzyme is a monomer that transfers a GMP cap onto the end of mRNA that terminates with a 5'-diphosphate tail.

Structural links Help

PDB - click here

SCOP: b.40.4.6

CATH: 2.40.50.140 , 4.10.87.10

Database links Help

Enzyme: EC:2.7.7.50

Pfam Clan: CL0021.14

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013846

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O55236 mRNA-capping enzyme

O60942 mRNA-capping enzyme

Q01159 mRNA-capping enzyme subunit alpha

Q17607 mRNA-capping enzyme

Q84424 mRNA-capping enzyme

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013846	mRNA capping enzyme, C-terminal
IPR017075	mRNA capping enzyme, alpha subunit
IPR017074	mRNA capping enzyme, bifunctional
IPR000387	Dual-specific/protein-tyrosine phosphatase, conserved region
IPR016027	Nucleic acid-binding, OB-fold-like
IPR016130	Protein-tyrosine phosphatase, active site
IPR000340	Dual specificity phosphatase, catalytic domain
IPR012340	Nucleic acid-binding, OB-fold
IPR001339	mRNA capping enzyme
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Hakansson K, Doherty AJ, Shuman S, Wigley DB. X-ray crystallography reveals a large conformational change during guanyl transfer by mRNA capping enzymes. Cell 89 545-53 1997 [PubMed: 9160746] http://dx.doi.org/10.1016/S0092-8674(00)80236-6

Additional Reading Open in usermanual
	Fabrega C, Shen V, Shuman S, Lima CD. Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II. Mol. Cell 11 2003 1549-61 [PubMed: 12820968] http://dx.doi.org/10.1016/S1097-2765(03)00187-4
	Hakansson K, Wigley DB. Structure of a complex between a cap analogue and mRNA guanylyl transferase demonstrates the structural chemistry of RNA capping. Proc. Natl. Acad. Sci. U.S.A. 95 1998 1505-10 [PubMed: 9465045] http://dx.doi.org/10.1073/pnas.95.4.1505

InterPro 24.0