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InterPro: IPR013784 Carbohydrate-binding-like fold

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UniProtKB

Matches:

2034 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR013784 Carb-bd-like_fold

Secondary

IPR002044

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF49452	CBD_4	2034
Signatures in BioMart

InterPro Relationships Help

Children

IPR002044 Glycoside hydrolase, carbohydrate-binding

Found in

IPR016590 Rhamnogalacturonase B
IPR019008 Protein of unknown function DUF2012

GO Term annotation Help

Function

GO:0030246 carbohydrate binding

InterPro annotation

Entry Details in BioMart

Abstract

This entry represents domains with a carbohydrate-binding-like fold, which consists of a seven-stranded beta-sandwich with a Greek key topology, although some members may have 1-2 extra strands. These domains are present as carbohydrate-binding modules in a number of glycosyl hydrolases, often at the C-terminal end, as well as in rhamnogalacturonase B (RhgB), where it occurs as a central domain [1, 2].

Structural links Help

PDB - click here

SCOP: b.1.18.2 , b.3.1.1 , b.3.1.2 , c.41.1.1

CATH: 2.60.40.10

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013784

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q10003 Uncharacterized protein T05H10.7

Q2QTC2 Phosphoglucan, water dikinase, chloroplastic

Q6ZY51 Phosphoglucan, water dikinase, chloroplastic

Q8C0L9 Putative glycerophosphodiester phosphodiesterase 5

Q9NPB8 Putative glycerophosphodiester phosphodiesterase 5

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002044	Glycoside hydrolase, carbohydrate-binding
IPR013815	ATP-grasp fold, subdomain 1
IPR013784	Carbohydrate-binding-like fold
IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR002192	Pyruvate phosphate dikinase, PEP/pyruvate-binding
IPR013783	Immunoglobulin-like fold
IPR004129	Glycerophosphoryl diester phosphodiesterase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Miyake H, Kurisu G, Kusunoki M, Nishimura S, Kitamura S, Nitta Y. Crystal structure of a catalytic site mutant of beta-amylase from Bacillus cereus var. mycoides cocrystallized with maltopentaose. Biochemistry 42 5574-81 2003 [PubMed: 12741813] http://dx.doi.org/10.1021/bi020712x
2.	McDonough MA, Kadirvelraj R, Harris P, Poulsen JC, Larsen S. Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4. FEBS Lett. 565 188-94 2004 [PubMed: 15135077] http://dx.doi.org/10.1016/j.febslet.2004.03.094

Additional Reading Open in usermanual
	Kim JS, Kluskens LD, de Vos WM, Huber R, van der Oost J. Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin. J. Mol. Biol. 335 2004 787-97 [PubMed: 14687574] http://dx.doi.org/10.1016/j.jmb.2003.11.006
	Kanai R, Haga K, Akiba T, Yamane K, Harata K. Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site. Protein Sci. 13 2004 457-65 [PubMed: 14739329] http://dx.doi.org/10.1110/ps.03408504
	Kelly RM, Leemhuis H, Rozeboom HJ, van Oosterwijk N, Dijkstra BW, Dijkhuizen L. Elimination of competing hydrolysis and coupling side reactions of a cyclodextrin glucanotransferase by directed evolution. Biochem. J. 413 2008 517-25 [PubMed: 18422488] http://dx.doi.org/10.1042/BJ20080353
	Leemhuis H, Rozeboom HJ, Dijkstra BW, Dijkhuizen L. Improved thermostability of bacillus circulans cyclodextrin glycosyltransferase by the introduction of a salt bridge. Proteins 54 2004 128-34 [PubMed: 14705029] http://dx.doi.org/10.1002/prot.10516

InterPro 23.1