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InterPro: IPR013750 GHMP kinase, C-terminal

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UniProtKB

Matches:

5223 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession

IPR013750 GHMP_kinase_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08544	GHMP_kinases_C	5223
Signatures in BioMart

InterPro Relationships Help

Found in

IPR000705 Galactokinase
IPR000870 Homoserine kinase
IPR001174 Galactokinase/homoserine kinase
IPR004422 GHMP kinase group 1
IPR004424 4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR005916 Phosphomevalonate kinase, eukaryotic
IPR005917 Phosphomevalonate kinase, Gram-positive
IPR005935 Diphosphomevalonate decarboxylase
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR010189 Shikimate kinase, archaea
IPR012043 GHMP kinase-like, archaeal
IPR012363 Propanediol utilisation/coumermycin biosynthesis, PduX-related
IPR012369 Galactokinase, glycosyltransferase
IPR014606 D,D-heptose 7-phosphate kinase
IPR016005 Phosphomevalonate kinase, ERG8

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in homoserine kinases (EC:2.7.1.39), galactokinases (EC:2.7.1.6) and mevalonate kinases (EC:2.7.1.36). These kinases make up the GHMP kinase superfamily of ATP-dependent enzymes [1]. These enzymes are involved in the biosynthesis of isoprenes and amino acids as well as in carbohydrate metabolism. The C-terminal domain of homoserine kinase has a central alpha-beta plait fold and an insertion of four helices, which, together with the N-terminal fold, create a novel nucleotide binding fold [2].

Structural links Help

PDB - click here

SCOP: d.58.26.1 , d.58.26.2 , d.58.26.3 , d.58.26.4 , d.58.26.5 , d.58.26.7

CATH: 3.30.70.890

Database links Help

Enzyme: EC:2.7.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013750

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O81014 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, chloroplastic

P04385 Galactokinase

P51570 Galactokinase

P72663 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Q99JF5 Diphosphomevalonate decarboxylase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR020568	Ribosomal protein S5 domain 2-type fold
IPR019741	Galactokinase, conserved site
IPR006206	Mevalonate/galactokinase
IPR006203	GHMP kinase, ATP-binding, conserved site
IPR006204	GHMP kinase
IPR013750	GHMP kinase, C-terminal
IPR005935	Diphosphomevalonate decarboxylase
IPR000705	Galactokinase
IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
IPR004424	4-diphosphocytidyl-2C-methyl-D-erythritol kinase
IPR019539	Galactokinase galactose-binding domain
	PDB Chain
	ModBase
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Bork P, Sander C, Valencia A. Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci. 2 31-40 1993 [PubMed: 8382990] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=8382990
2.	Zhou T, Daugherty M, Grishin NV, Osterman AL, Zhang H. Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. Structure 8 1247-57 2000 [PubMed: 11188689] http://dx.doi.org/10.1016/S0969-2126(00)00533-5

Additional Reading Open in usermanual
	Fu Z, Voynova NE, Herdendorf TJ, Miziorko HM, Kim JJ. Biochemical and structural basis for feedback inhibition of mevalonate kinase and isoprenoid metabolism. Biochemistry 47 2008 3715-24 [PubMed: 18302342] http://dx.doi.org/10.1021/bi7024386
	Wada T, Kuzuyama T, Satoh S, Kuramitsu S, Yokoyama S, Unzai S, Tame JR, Park SY. Crystal structure of 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase, an enzyme in the non-mevalonate pathway of isoprenoid synthesis. J. Biol. Chem. 278 2003 30022-7 [PubMed: 12771135] http://dx.doi.org/10.1074/jbc.M304339200
	Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ. Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins 60 2005 787-96 [PubMed: 16021622] http://dx.doi.org/10.1002/prot.20541
	Hartley A, Glynn SE, Barynin V, Baker PJ, Sedelnikova SE, Verhees C, de Geus D, van der Oost J, Timson DJ, Reece RJ, Rice DW. Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase. J. Mol. Biol. 337 2004 387-98 [PubMed: 15003454] http://dx.doi.org/10.1016/j.jmb.2004.01.043
	Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. J. Biol. Chem. 280 2005 9662-70 [PubMed: 15590630] http://dx.doi.org/10.1074/jbc.M412916200

InterPro 23.1