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InterPro: IPR013738 Beta-galactosidase trimerisation

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UniProtKB

Matches:

480 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR013738 Beta_Galactosidase_Trimer

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08532	Glyco_hydro_42M	480
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003476 Glycoside hydrolase, family 42

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0004565 beta-galactosidase activity

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

This is non catalytic domain B of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. This domain is related to glutamine amidotransferase enzymes, but the catalytic residues are replaced by non functional amino acids. This domain is involved in trimerisation.

Structural links Help

PDB - click here

SCOP: c.23.16.5

CATH: 3.40.50.880

Database links Help

Enzyme: EC:3.2.1.23

Pfam Clan: CL0014.18

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013738

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O69315 Beta-galactosidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013739	Beta-galactosidase C-terminal
IPR013738	Beta-galactosidase trimerisation
IPR013529	Glycoside hydrolase, family 42, N-terminal
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR013780	Glycosyl hydrolase, family 13, all-beta
IPR017853	Glycoside hydrolase, catalytic core
IPR003476	Glycoside hydrolase, family 42
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999

Additional Reading Open in usermanual
	Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J. Mol. Biol. 322 2002 79-91 [PubMed: 12215416] http://dx.doi.org/10.1016/S0022-2836(02)00746-5
	Shimizu T, Kobayashi T, Ba-Thein W, Ohtani K, Hayashi H. Sequence analysis of flanking regions of the pfoA gene of Clostridium perfringens: beta-galactosidase gene (pbg) is located in the 3'-flanking region. Microbiol. Immunol. 39 1995 677-86 [PubMed: 8577281]

InterPro 23.1