EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR013708 Shikimate dehydrogenase substrate binding, N-terminal

Protein matches Help

UniProtKB

Matches:

2729 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR013708 Shikimate_DH-bd_N

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08501	Shikimate_dh_N	2729
Signatures in BioMart

InterPro Relationships Help

Found in

IPR008289 Pentafunctional AroM protein
IPR010110 Shikimate-5-dehydrogenase
IPR011342 Quinate/shikimate 5-dehydrogenase

InterPro annotation

Entry Details in BioMart

Abstract

This domain is the substrate binding domain of shikimate dehydrogenase [1]. Shikimate dehydrogenase catalyses the fourth step of the mycobacterial Shikimate pathway, which results in the biosynthesis of chorismate. Chorismate is a precursor of aromatic amino acids, naphthoquinones, menaquinones and mycobactins [2, 3]. This pathway is an important target for antibacterial agents, especially against Mycobacterium tuberculosis, since it does not occur in mammals.

Structural links Help

PDB - click here

SCOP: c.58.1.5

CATH: 3.40.192.10

Database links Help

Enzyme: EC:1.1.1.25

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013708

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O67049 Shikimate dehydrogenase

P08566 Pentafunctional AROM polypeptide

P74591 Shikimate dehydrogenase

Q58484 Shikimate dehydrogenase

Q9SQT8 Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013785	Aldolase-type TIM barrel
IPR013792	RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
IPR002658	3-dehydroquinate synthase AroB
IPR013708	Shikimate dehydrogenase substrate binding, N-terminal
IPR010110	Shikimate-5-dehydrogenase
IPR008289	Pentafunctional AroM protein
IPR011342	Quinate/shikimate 5-dehydrogenase
IPR016037	3-dehydroquinate synthase AroB, subgroup
IPR018508	3-dehydroquinate dehydratase, active site
IPR001381	Dehydroquinase class I
IPR000623	Shikimate kinase
IPR016040	NAD(P)-binding domain
IPR006151	Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase
IPR006264	3-phosphoshikimate 1-carboxyvinyltransferase, subgroup
IPR001986	3-phosphoshikimate 1-carboxyvinyltransferase, core
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. J. Biol. Chem. 280 17101-8 2005 [PubMed: 15735308] http://dx.doi.org/10.1074/jbc.M412753200
2.	Arcuri HA, Borges JC, Fonseca IO, Pereira JH, Neto JR, Basso LA, Santos DS, de Azevedo WF Jr. Structural studies of shikimate 5-dehydrogenase from Mycobacterium tuberculosis. Proteins 72 720-30 2008 [PubMed: 18260104] http://dx.doi.org/10.1002/prot.21953
3.	Michel G, Roszak AW, Sauve V, Maclean J, Matte A, Coggins JR, Cygler M, Lapthorn AJ. Structures of shikimate dehydrogenase AroE and its Paralog YdiB. A common structural framework for different activities. J. Biol. Chem. 278 19463-72 2003 [PubMed: 12637497] http://dx.doi.org/10.1074/jbc.M300794200

Additional Reading Open in usermanual
	Bagautdinov B, Kunishima N. Crystal structures of shikimate dehydrogenase AroE from Thermus thermophilus HB8 and its cofactor and substrate complexes: insights into the enzymatic mechanism. J. Mol. Biol. 373 2007 424-38 [PubMed: 17825835] http://dx.doi.org/10.1016/j.jmb.2007.08.017
	Gan J, Wu Y, Prabakaran P, Gu Y, Li Y, Andrykovitch M, Liu H, Gong Y, Yan H, Ji X. Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism. Biochemistry 46 2007 9513-22 [PubMed: 17649975] http://dx.doi.org/10.1021/bi602601e
	Badger J, Sauder JM, Adams JM, Antonysamy S, Bain K, Bergseid MG, Buchanan SG, Buchanan MD, Batiyenko Y, Christopher JA, Emtage S, Eroshkina A, Feil I, Furlong EB, Gajiwala KS, Gao X, He D, Hendle J, Huber A, Hoda K, Kearins P, Kissinger C, Laubert B, Lewis HA, Lin J, Loomis K, Lorimer D, Louie G, Maletic M, Marsh CD, Miller I, Molinari J, Muller-Dieckmann HJ, Newman JM, Noland BW, Pagarigan B, Park F, Peat TS, Post KW, Radojicic S, Ramos A, Romero R, Rutter ME, Sanderson WE, Schwinn KD, Tresser J, Winhoven J, Wright TA, Wu L, Xu J, Harris TJ. Structural analysis of a set of proteins resulting from a bacterial genomics project. Proteins 60 2005 787-96 [PubMed: 16021622] http://dx.doi.org/10.1002/prot.20541

InterPro 23.1