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InterPro: IPR013529 Glycoside hydrolase, family 42, N-terminal

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UniProtKB

Matches:

525 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR013529 Glyco_hydro_42_N

Secondary

IPR003476

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF02449	Glyco_hydro_42	525
Signatures in BioMart

InterPro Relationships Help

Found in

IPR003476 Glycoside hydrolase, family 42

Contains

IPR013781 Glycoside hydrolase, subgroup, catalytic core

GO Term annotation Help

Process

GO:0005975 carbohydrate metabolic process

Function

GO:0004565 beta-galactosidase activity

Component

GO:0009341 beta-galactosidase complex

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

This group of beta-galactosidase enzymes (EC:3.2.1.23) belong to the glycosyl hydrolase 42 family GH42. The enzyme catalyses the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.

Structural links Help

PDB - click here

SCOP: c.1.8.1

CATH: 3.20.20.80

Database links Help

Enzyme: EC:3.2.1.23

Pfam Clan: CL0058.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR013529

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O69315 Beta-galactosidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013739	Beta-galactosidase C-terminal
IPR013738	Beta-galactosidase trimerisation
IPR013529	Glycoside hydrolase, family 42, N-terminal
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR013780	Glycosyl hydrolase, family 13, all-beta
IPR017853	Glycoside hydrolase, catalytic core
IPR003476	Glycoside hydrolase, family 42
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999

Additional Reading Open in usermanual
	Hidaka M, Fushinobu S, Ohtsu N, Motoshima H, Matsuzawa H, Shoun H, Wakagi T. Trimeric crystal structure of the glycoside hydrolase family 42 beta-galactosidase from Thermus thermophilus A4 and the structure of its complex with galactose. J. Mol. Biol. 322 2002 79-91 [PubMed: 12215416] http://dx.doi.org/10.1016/S0022-2836(02)00746-5
	Shimizu T, Kobayashi T, Ba-Thein W, Ohtani K, Hayashi H. Sequence analysis of flanking regions of the pfoA gene of Clostridium perfringens: beta-galactosidase gene (pbg) is located in the 3'-flanking region. Microbiol. Immunol. 39 1995 677-86 [PubMed: 8577281]

InterPro 23.1