InterPro: IPR013319 Glycoside hydrolase, family 11/12, catalytic domain

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

Glycoside hydrolase family 11 GH11 comprises enzymes with only one known activity, xylanase (EC:3.2.1.8), while family 12 GH12 comprises enzymes with two known activities, endoglucanase (EC:3.2.1.4) and xyloglucan hydrolase. This entry represents the catalytic core of family 11 and 12 glycoside hydrolases, which assumes a beta-sandwich structure of complex topology, consisting of 12-14 beta-strands in two sheets.