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InterPro: IPR013234 PIGA, GPI anchor biosynthesis

Protein matches Help

UniProtKB

Matches:

152 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR013234 PIGA_GPI_anchor_biosynthesis

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08288	PIGA	152
Signatures in BioMart

GO Term annotation Help

Process

GO:0006506 GPI anchor biosynthetic process

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found on phosphatidylinositol N-acetylglucosaminyltransferase proteins. These proteins are involved in GPI anchor biosynthesis and are associated with the disease paroxysmal nocturnal haemoglobinuria [1].

Database links Help

Enzyme: EC:2.4.1.198

Taxonomic coverage Help

Example proteins Help

A6ZW78 Phosphatidylinositol N-acetylglucosaminyltransferase GPI3 subunit

P37287 Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

P87172 Phosphatidylinositol N-acetylglucosaminyltransferase gpi3 subunit

Q64323 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013234	PIGA, GPI anchor biosynthesis
IPR001296	Glycosyl transferase, group 1
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Kulkarni S, Bessler M. The effect of GPI-anchor deficiency on apoptosis in mice carrying a Piga gene mutation in hematopoietic cells. J. Leukoc. Biol. 72 1228-33 2002 [PubMed: 12488505] http://www.jleukbio.org/cgi/content/abstract/72/6/1228

InterPro 23.1