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InterPro: IPR012939 Glycosyl hydrolase 92

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UniProtKB

Matches:

813 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR012939 Glyco_hydro_92

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07971	Glyco_hydro_92	813
Signatures in BioMart

InterPro Relationships Help

Found in

IPR005887 Alpha-1,2-mannosidase, putative

InterPro annotation

Entry Details in BioMart

Abstract

This domain occurs within alpha-1,2-mannosidases, which remove alpha-1,2-linked mannose residues from Man(9)(GlcNAc)(2) by hydrolysis. They are critical for the maturation of N-linked oligosaccharides and ER-associated degradation [1].

Database links Help

PANDIT: PF07971

Blocks: IPB012939

Pfam Clan: CL0058.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR012939

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0AXG4 Putative alpha-1,2-mannosidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR005887	Alpha-1,2-mannosidase, putative
IPR012939	Glycosyl hydrolase 92

Publications Open in usermanual
1.	Liu Y, Choudhury P, Cabral CM, Sifers RN. Oligosaccharide modification in the early secretory pathway directs the selection of a misfolded glycoprotein for degradation by the proteasome. J. Biol. Chem. 274 5861-7 1999 [PubMed: 10026209] http://dx.doi.org/10.1074/jbc.274.9.5861

Additional Reading Open in usermanual
	Naumoff DG. GH97 is a new family of glycoside hydrolases, which is related to the alpha-galactosidase superfamily. BMC Genomics 6 2005 112 [PubMed: 16131397] http://dx.doi.org/10.1186/1471-2164-6-112

InterPro 23.1