InterPro: IPR012705 2-methylcitrate dehydratase PrpD

At least five distinct pathways exist for the catabolism of propionate by way of propionyl-CoA. Most members of this family are bacterial proteins known or predicted to act as 2-methylcitrate dehydratase; an enzyme which catalyses the third step the methylcitrate cycle of propionate catabolism [1]. A related clade of archaeal proteins that may or may not be functionally equivalent is excluded from this family. The PrpD enzyme of Escherichia coli is responsible for the minor aconitase activity (AcnC) not accounted for by AcnA and AcnB [2]. Some proteins in this entry are annotated as MmgE, a Bacillus subtilis protein encoded within an operon which is expressed during sporulation, subject to catabolite repression [3].