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InterPro: IPR012553 Defensin-like peptide

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UniProtKB

Matches:

6 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR012553 Defensin_3

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF08131	Defensin_3	6
Signatures in BioMart

GO Term annotation Help

Component

GO:0005576 extracellular region

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of the defensin-like peptides (DLPs) isolated from platypus venom. These DLPs show similar three-dimensional fold to that of beta-defensin-12 and sodium-channel neurotoxin Shl. However the side chains known to be functionally important to beta-defensin-12 and Shl are not conserved in DLPs. This suggests a different biological function. Consistent with this contention, DLPs have been shown to possess no anti-microbial properties and have no observable activity on rat dorsal-root-ganglion sodium-channel currents [1].

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SCOP: g.9.1.1

CATH: 2.20.20.10

Database links Help

Blocks: IPB012553

Pfam Clan: CL0075.9

Taxonomic coverage Help

Example proteins Help

P82140 Defensin-like peptide 2/4

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012553	Defensin-like peptide
	PDB Chain
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Torres AM, Wang X, Fletcher JI, Alewood D, Alewood PF, Smith R, Simpson RJ, Nicholson GM, Sutherland SK, Gallagher CH, King GF, Kuchel PW. Solution structure of a defensin-like peptide from platypus venom. Biochem. J. 341 ( Pt 3) 785-94 1999 [PubMed: 10417345] http://dx.doi.org/10.1042/0264-6021:3410785

Additional Reading Open in usermanual
	Torres AM, de Plater GM, Doverskog M, Birinyi-Strachan LC, Nicholson GM, Gallagher CH, Kuchel PW. Defensin-like peptide-2 from platypus venom: member of a class of peptides with a distinct structural fold. Biochem. J. 348 Pt 3 2000 649-56 [PubMed: 10839998] http://dx.doi.org/10.1042/0264-6021:3480649
	Torres AM, Tsampazi C, Geraghty DP, Bansal PS, Alewood PF, Kuchel PW. D-amino acid residue in a defensin-like peptide from platypus venom: effect on structure and chromatographic properties. Biochem. J. 391 2005 215-20 [PubMed: 16033333] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=16033333

InterPro 23.1