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InterPro: IPR012477 Glycosyltransferase family 52

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UniProtKB

Matches:

76 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession List
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Accession

IPR012477 Glyco_transf_52

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07922	Glyco_transf_52	76
Signatures in BioMart

GO Term annotation Help

Process

GO:0009103 lipopolysaccharide biosynthetic process

Function

GO:0008373 sialyltransferase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family features glycosyltransferases belonging to glycosyltransferase family 52 [1], which have alpha-2,3- sialyltransferase (EC:4.2.99.4) and alpha-glucosyltransferase (EC:2.4.1) activity. For example, beta-galactoside alpha-2,3- sialyltransferase expressed by Neisseria meningitidis (P72097)is a member of this family and is involved in a step of lipooligosaccharide biosynthesis requiring sialic acid transfer; these lipooligosaccharides are thought to be important in the process of pathogenesis [2].

Database links Help

Enzyme: EC:2.4.99

PANDIT: PF07922

Blocks: IPB012477

Taxonomic coverage Help

Example proteins Help

P72074 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012477	Glycosyltransferase family 52

Publications Open in usermanual
1.	Coutinho PM, Deleury E, Davies GJ, Henrissat B. An evolving hierarchical family classification for glycosyltransferases. J. Mol. Biol. 328 307-17 2003 [PubMed: 12691742] http://dx.doi.org/10.1016/S0022-2836(03)00307-3
2.	Gilbert M, Watson DC, Cunningham AM, Jennings MP, Young NM, Wakarchuk WW. Cloning of the lipooligosaccharide alpha-2,3-sialyltransferase from the bacterial pathogens Neisseria meningitidis and Neisseria gonorrhoeae. J. Biol. Chem. 271 28271-6 1996 [PubMed: 8910446] http://dx.doi.org/10.1074/jbc.271.45.28271

InterPro 23.1