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InterPro: IPR012364 Oligosaccharide lyase

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11 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR012364 Oligosacch_lyase

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF034409	Oligosach_lyase	11
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

The Sphingomonas sp. A1 member of this group has been characterised as oligoalginate lyase [1].

Sphingomonas sp. can transport alginate into cells and then depolymerise it to di- and tri-saccharides by three kinds of cytoplasmic alginate lyases (A1-I, A1-II, and A1-III). The resultant alginate oligosaccharides are degraded to monosaccharides by cytoplasmic oligoalginate lyase [2]. The reaction catalysed by the Sphingomonas sp. oligoalginate lyase is exolytic. This enzyme is encoded by a gene located downstream of the genes coding for the precursor of alginate lyases (aly) and the ABC transporter (algS, algM1, and algM2) which are other genes for proteins required for the transport and complete depolymerisation of alginate [1].

Detailed sequence analysis shows sequence motifs conserved throughout this group of proteins. Therefore, other members of this group are predicted to be oligosaccharide lyases, but their exact substrates are unknown.

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Overlapping InterPro entries Help

IPR012364

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A7M5S2 Putative uncharacterized protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR012364	Oligosaccharide lyase
IPR012480	Heparinase II/III-like
	SWISS-MODEL

Publications Open in usermanual
1.	Hashimoto W, Miyake O, Momma K, Kawai S, Murata K. Molecular identification of oligoalginate lyase of Sphingomonas sp. strain A1 as one of the enzymes required for complete depolymerization of alginate. J. Bacteriol. 182 4572-7 2000 [PubMed: 10913091] http://dx.doi.org/10.1128/JB.182.16.4572-4577.2000
2.	Miyake O, Hashimoto W, Murata K. An exotype alginate lyase in Sphingomonas sp. A1: overexpression in Escherichia coli, purification, and characterization of alginate lyase IV (A1-IV). Protein Expr. Purif. 29 33-41 2003 [PubMed: 12729723] http://dx.doi.org/10.1016/S1046-5928(03)00018-4

InterPro 23.1