InterPro: IPR012329 Polysaccharide lyase family 8, N-terminal

Proteins containing this N-terminal domain consist of a group of secreted bacterial lyase enzymes capable of acting on a variety of substrates. One such enzyme is hyaluronate lyase, a Streptococcal surface enzyme that degrades hyaluronan and chondroitin, thereby helping to spread the bacteria throughout host tissues [1]. Hyaluronate lyase (EC:4.2.2.1) is a four-domain enzyme containing an N-terminal carbohydrate-binding domain, a spacer domain, a catalytic domain, and a C-terminal domain that modulates access to the catalytic cleft of the enzyme. The N-terminal domain is multi-helical, with up to seven alpha-hairpins arranged in a closed circular array. Other bacterial enzymes that display this structure include the N-terminal domain of chondroitin AC lyase (EC:4.2.2.5) [2], and the N-terminal domain of xanthan lyase (EC:4.2.2.12) [3]. This entry represents the N-terminal domain of hyaluronate lyase, chondroitin AC lyase and xanthan lyase.