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InterPro: IPR012045 Peptidase M6, unassigned InhA-related

Protein matches Help

UniProtKB

Matches:

32 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR012045 Pept_M6_InhA_rel

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF036597	Protse_InhA_rel	32
Signatures in BioMart

InterPro Relationships Help

Contains

IPR018247 EF-Hand 1, calcium-binding site
IPR020008 Gammaproteobacterial enzyme, C-terminal transmembrane domain

InterPro annotation

Entry Details in BioMart

Abstract

This group of proteins are related to the secreted virulence peptidase InhA (IPR008757) and along with InhA belong to MEROPS peptidase family M6 (immune inhibitor A, clan MA). On the basis of sequence similarity, and a conserved HEXXHXXGXXD motif, where the two histidines and the aspartate are zinc ligands and the glutamate is the catalytic residue it can be predicted that all members are peptidases.

Annotation note: due to the presence of PKD repeats in some of the members of this group, spurious similarity hits may appear (involving unrelated proteins), which may lead to the erroneous transfer of functional annotations and protein names.

Database links Help

MEROPS: M6

Taxonomic coverage Help