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InterPro: IPR011894 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate

Protein matches Help

UniProtKB

Matches:

346 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011894 PorC_KorC

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR02175	PorC_KorC	346
Signatures in BioMart

InterPro Relationships Help

Parent

IPR019752 Pyruvate/ketoisovalerate oxidoreductase

Contains

IPR002869 Pyruvate-flavodoxin oxidoreductase, central domain

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

InterPro annotation

Entry Details in BioMart

Abstract

A number of anaerobic and microaerophilic species lack pyruvate dehydrogenase and have instead a four subunit, oxygen-sensitive pyruvate oxidoreductase, with either ferredoxins or flavodoxins (Helicobacter pylori (Campylobacter pylori)) used as the acceptor. Several related four-subunit enzymes may exist in the same species. This entry describes the gamma subunit. In Pyrococcus furiosus, enzymes active on pyruvate and 2-ketoisovalerate share a common gamma subunit [1].

Database links Help

Enzyme: EC:1.2.7.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011894

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O05650 Pyruvate synthase subunit porC

O27772 Pyruvate synthase subunit porC

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002869	Pyruvate-flavodoxin oxidoreductase, central domain
IPR011894	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate
IPR019752	Pyruvate/ketoisovalerate oxidoreductase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Kletzin A, Adams MW. Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima. J. Bacteriol. 178 248-57 1996 [PubMed: 8550425] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=8550425&action=stream&blobtype=pdf

InterPro 23.1