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InterPro: IPR011816 Penicillin-binding protein 1A

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UniProtKB

Matches:

2459 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession

IPR011816 PBP_1a

Type

Domain

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR02074	PBP_1a_fam	2459
Signatures in BioMart

InterPro Relationships Help

Contains

IPR001264 Glycosyl transferase, family 51
IPR001460 Penicillin-binding protein, transpeptidase

GO Term annotation Help

Process

GO:0009252 peptidoglycan biosynthetic process
GO:0046677 response to antibiotic

Function

GO:0008233 peptidase activity
GO:0016763 transferase activity, transferring pentosyl groups

InterPro annotation

Entry Details in BioMart

Abstract

Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (IPR011813). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages.

Structural links Help

PDB - click here

SCOP: d.2.1.10 , e.3.1.1

Database links Help

Enzyme: EC:2.4.2 , EC:3.4

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011816

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O66874 Penicillin-binding protein 1A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011816	Penicillin-binding protein 1A
IPR001264	Glycosyl transferase, family 51
IPR001460	Penicillin-binding protein, transpeptidase
IPR012338	Beta-lactamase-type transpeptidase fold
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Di Guilmi AM, Mouz N, Andrieu JP, Hoskins J, Jaskunas SR, Gagnon J, Dideberg O, Vernet T. Identification, purification, and characterization of transpeptidase and glycosyltransferase domains of Streptococcus pneumoniae penicillin-binding protein 1a. J. Bacteriol. 180 1998 5652-9 [PubMed: 9791115]
	Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc. Natl. Acad. Sci. U.S.A. 104 2007 5348-53 [PubMed: 17360321] http://dx.doi.org/10.1073/pnas.0701160104
	Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem. Biol. 3 2008 429-36 [PubMed: 18642800]
	Contreras-Martel C, Job V, Di Guilmi AM, Vernet T, Dideberg O, Dessen A. Crystal structure of penicillin-binding protein 1a (PBP1a) reveals a mutational hotspot implicated in beta-lactam resistance in Streptococcus pneumoniae. J. Mol. Biol. 355 2006 684-96 [PubMed: 16316661] http://dx.doi.org/10.1016/j.jmb.2005.10.030
	Job V, Di Guilmi AM, Martin L, Vernet T, Dideberg O, Dessen A. Structural studies of the transpeptidase domain of PBP1a from Streptococcus pneumoniae. Acta Crystallogr. D Biol. Crystallogr. 59 2003 1067-9 [PubMed: 12777776] http://dx.doi.org/10.1107/S0907444903006954

InterPro 23.1