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InterPro: IPR011806 Sulphite reductase, dissimilatory-type alpha subunit

Protein matches Help

UniProtKB

Matches:

1349 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011806 DsrA

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR02064	dsrA	1349
Signatures in BioMart

InterPro Relationships Help

Contains

IPR006067 Nitrite/sulphite reductase 4Fe-4S domain
IPR017896 4Fe-4S ferredoxin, iron-sulpur binding domain

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0018551 hydrogensulfite reductase activity
GO:0020037 heme binding
GO:0051539 4 iron, 4 sulfur cluster binding

InterPro annotation

Entry Details in BioMart

Abstract

Dissimilatory sulphite reductase catalyzes the six-electron reduction of sulphite to sulphide, as the terminal reaction in dissimilatory sulphate reduction. It remains unclear however, whether trithionate and thiosulphate serve as intermediate compounds to sulphide, or as end products of sulphite reduction [1]. Sulphite reductase is a multisubunit enzyme composed of dimers of either alpha/beta or alpha/beta/gamma subunits, each containing a siroheme and iron sulphur cluster prosthetic centre [2]. Found in sulphate-reducing bacteria, these genes are commonly located in a unidirectional gene cluster [3].

Structural links Help

PDB - click here

SCOP: d.134.1.1 , d.58.1.5 , d.58.36.2

Database links Help

Enzyme: EC:1.8.99.3

PRIAM: PRI002226

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011806

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P45574 Sulfite reductase, dissimilatory-type subunit alpha

Q59109 Sulfite reductase, dissimilatory-type subunit alpha

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006067	Nitrite/sulphite reductase 4Fe-4S domain
IPR011806	Sulphite reductase, dissimilatory-type alpha subunit
IPR017896	4Fe-4S ferredoxin, iron-sulpur binding domain
IPR005117	Nitrite/sulphite reductase, hemoprotein beta-component, ferrodoxin-like
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Hansen TA. Metabolism of sulfate-reducing prokaryotes. Antonie Van Leeuwenhoek 66 165-85 1994 [PubMed: 7747930] http://dx.doi.org/10.1007/BF00871638
2.	Pierik AJ, Duyvis MG, van Helvoort JM, Wolbert RB, Hagen WR. The third subunit of desulfoviridin-type dissimilatory sulfite reductases. Eur. J. Biochem. 205 111-5 1992 [PubMed: 1555572] http://dx.doi.org/10.1111/j.1432-1033.1992.tb16757.x
3.	Larsen O , Lien T, Birkeland NK. A novel organization of the dissimilatory sulfite reductase operon of Thermodesulforhabdus norvegica verified by RT-PCR. FEMS Microbiol. Lett. 203 81-5 2001 [PubMed: 11557144] http://dx.doi.org/10.1111/j.1574-6968.2001.tb10824.x

Additional Reading Open in usermanual
	Schiffer A, Parey K, Warkentin E, Diederichs K, Huber H, Stetter KO, Kroneck PM, Ermler U. Structure of the dissimilatory sulfite reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus. J. Mol. Biol. 379 2008 1063-74 [PubMed: 18495156] http://dx.doi.org/10.1016/j.jmb.2008.04.027
	Oliveira TF, Vonrhein C, Matias PM, Venceslau SS, Pereira IA, Archer M. Purification, crystallization and preliminary crystallographic analysis of a dissimilatory sulfite reductase DsrAB in complex with DsrC. J. Struct. Biol. 2008 [PubMed: 18706503]
	Oliveira TF, Vonrhein C, Matias PM, Venceslau SS, Pereira IA, Archer M. The crystal structure of Desulfovibrio vulgaris dissimilatory sulfite reductase bound to DsrC provides novel insights into the mechanism of sulfate respiration. J. Biol. Chem. 283 2008 34141-9 [PubMed: 18829451] http://dx.doi.org/10.1074/jbc.M805643200

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