EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR011800 Phosphoadenosine phosphosulphate reductase thioredoxin

Protein matches Help

UniProtKB

Matches:

319 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011800 PAPS_reductase

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR02057	PAPS_reductase	319
Signatures in BioMart

InterPro Relationships Help

Parent

IPR004511 Phosphoadenosine phosphosulphate reductase CysH-type

Contains

IPR002500 Phosphoadenosine phosphosulphate reductase

GO Term annotation Help

Process

GO:0019344 cysteine biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin) activity

InterPro annotation

Entry Details in BioMart

Abstract

Requiring thioredoxin as an electron donor, phosphoadenosine phosphosulphate reductase catalyzes the reduction of 3'-phosphoadenylylsulphate (PAPS) to sulphite and phospho-adenosine-phosphate (PAP). Found in enterobacteria, cyanobacteria, and yeast, PAPS reductase is related to a group of plant (IPR004508) and bacterial (IPR011798) enzymes preferring 5'-adenylylsulphate (APS) over PAPS as a substrate for reduction to sulphite.

Structural links Help

PDB - click here

SCOP: c.26.2.2

CATH: 3.40.50.620

Database links Help

Enzyme: EC:1.8.4.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011800

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

B1XN08 Phosphoadenosine phosphosulfate reductase

P17854 Phosphoadenosine phosphosulfate reductase

P18408 Phosphoadenosine phosphosulfate reductase

P56859 Phosphoadenosine phosphosulfate reductase

P72794 Phosphoadenosine phosphosulfate reductase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold
IPR011800	Phosphoadenosine phosphosulphate reductase thioredoxin
IPR004511	Phosphoadenosine phosphosulphate reductase CysH-type
IPR002500	Phosphoadenosine phosphosulphate reductase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Help

Additional Reading Open in usermanual
	Savage H, Montoya G, Svensson C, Schwenn JD, Sinning I. Crystal structure of phosphoadenylyl sulphate (PAPS) reductase: a new family of adenine nucleotide alpha hydrolases. Structure 5 1997 895-906 [PubMed: 9261082] http://dx.doi.org/10.1016/S0969-2126(97)00244-X
	Bick JA, Dennis JJ, Zylstra GJ, Nowack J, Leustek T. Identification of a new class of 5'-adenylylsulfate (APS) reductases from sulfate-assimilating bacteria. J. Bacteriol. 182 2000 135-42 [PubMed: 10613872] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=10613872

InterPro 23.1