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InterPro: IPR011708 Bacterial DNA polymerase III, alpha subunit

Protein matches Help

UniProtKB

Matches:

2962 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011708 DNA_pol3_alpha

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07733	DNA_pol3_alpha	2962
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004805 DNA polymerase III, alpha subunit
IPR006308 DNA polymerase III, alpha subunit, Gram-positive type

GO Term annotation Help

Process

GO:0006260 DNA replication

Function

GO:0008408 3'-5' exonuclease activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

This is a conserved region found in the the DNA polymerase III alpha subunit, (EC:2.7.7.7). DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase.

Database links Help

Enzyme: EC:2.7.7.7

PANDIT: PF07733

Blocks: IPB011708

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011708

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P10443 DNA polymerase III subunit alpha

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR003141	Polymerase/histidinol phosphatase, N-terminal
IPR004013	PHP, C-terminal
IPR016195	Polymerase/histidinol phosphatase-like
IPR004365	Nucleic acid binding, OB-fold, tRNA/helicase-type
IPR016027	Nucleic acid-binding, OB-fold-like
IPR011708	Bacterial DNA polymerase III, alpha subunit
IPR004805	DNA polymerase III, alpha subunit
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Help

Additional Reading Open in usermanual
	Aravind L, Koonin EV. Phosphoesterase domains associated with DNA polymerases of diverse origins. Nucleic Acids Res. 26 1998 3746-52 [PubMed: 9685491] http://dx.doi.org/10.1093/nar/26.16.3746

InterPro 23.1