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InterPro: IPR011683 Glycosyl hydrolase 53

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UniProtKB

Matches:

240 proteins

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Accession

IPR011683 Glyco_hydro_53

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07745	Glyco_hydro_53	240
Signatures in BioMart

InterPro Relationships Help

Contains

IPR013781 Glycoside hydrolase, subgroup, catalytic core

GO Term annotation Help

Function

GO:0015926 glucosidase activity

InterPro annotation

Entry Details in BioMart

Abstract

O-Glycosyl hydrolases EC:3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [1, 2, 3]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site [4]. Because the fold of proteins is better conserved than their sequences, some of the families can be grouped in clans.

This domain is found in family 53 of the glycosyl hydrolase classification [5]. These enzymes are endo-1,4- beta-galactanases (EC:3.2.1.89). The structure of this domain is known [6] and has a TIM barrel fold.

Structural links Help

PDB - click here

SCOP: c.1.8.3

CATH: 3.20.20.80

Database links Help

Enzyme: EC:3.2.1.89

PANDIT: PF07745

Blocks: IPB011683

Pfam Clan: CL0058.12

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011683

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P48842 Arabinogalactan endo-1,4-beta-galactosidase

Q65CX5 Arabinogalactan endo-1,4-beta-galactosidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011683	Glycosyl hydrolase 53
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR017853	Glycoside hydrolase, catalytic core
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G. Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases. Proc. Natl. Acad. Sci. U.S.A. 92 7090-4 1995 [PubMed: 7624375] http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=EBI&pubmedid=7624375&action=stream&blobtype=pdf
2.	Davies G, Henrissat B. Structures and mechanisms of glycosyl hydrolases. Structure 3 853-9 1995 [PubMed: 8535779] http://dx.doi.org/10.1016/S0969-2126(01)00220-9
3.	Bairoch A. Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT. 1999
4.	Henrissat B, Coutinho PM. Carbohydrate-Active Enzymes server. 1999
5.	Coutinho PM, Deleury E, Davies GJ, Henrissat B. An evolving hierarchical family classification for glycosyltransferases. J. Mol. Biol. 328 307-17 2003 [PubMed: 12691742] http://dx.doi.org/10.1016/S0022-2836(03)00307-3
6.	Ryttersgaard C, Lo Leggio L, Coutinho PM, Henrissat B, Larsen S. Aspergillus aculeatus beta-1,4-galactanase: substrate recognition and relations to other glycoside hydrolases in clan GH-A. Biochemistry 41 15135-43 2002 [PubMed: 12484750] http://dx.doi.org/10.1021/bi026238c

Additional Reading Open in usermanual
	Le Nours J, Ryttersgaard C, Lo Leggio L, Ostergaard PR, Borchert TV, Christensen LL, Larsen S. Structure of two fungal beta-1,4-galactanases: searching for the basis for temperature and pH optimum. Protein Sci. 12 2003 1195-204 [PubMed: 12761390] http://dx.doi.org/10.1110/ps.0300103
	Ryttersgaard C, Le Nours J, Lo Leggio L, Jorgensen CT, Christensen LL, Bjornvad M, Larsen S. The structure of endo-beta-1,4-galactanase from Bacillus licheniformis in complex with two oligosaccharide products. J. Mol. Biol. 341 2004 107-17 [PubMed: 15312766] http://dx.doi.org/10.1016/j.jmb.2004.05.017

InterPro 23.1