EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR011611 Carbohydrate/purine kinase

Protein matches Help

UniProtKB

Matches:

9680 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011611 Carb/pur_kinase

Secondary

IPR002173

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00294	PfkB	9680
Signatures in BioMart

InterPro Relationships Help

Children

IPR011913 RfaE bifunctional protein, domain I

Found in

IPR001805 Adenosine kinase
IPR002139 Ribokinase
IPR004625 Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase
IPR005926 Tagatose-6-phosphate kinase
IPR011877 Ribokinase, bacterial
IPR016831 Uncharacterised conserved protein UCP025725, kinase-related
IPR017583 1-phosphofructokinase

Contains

IPR002173 Carbohydrate/puine kinase, PfkB, conserved site

InterPro annotation

Entry Details in BioMart

Abstract

This entry includes a variety of carbohydrate and pyrimidine kinases. The family includes phosphomethylpyrimidine kinase (EC:2.7.4.7). This enzyme is part of the Thiamine pyrophosphate (TPP) synthesis pathway, TPP is an essential cofactor for many enzymes [1].

Structural links Help

PDB - click here

SCOP: c.72.1.1 , c.72.1.5

CATH: 3.30.1110.10 , 3.40.1190.20

Database links Help

Enzyme: EC:2.7.1

PANDIT: PF00294

Blocks: IPB011611

Pfam Clan: CL0118.8

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011611

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O00764 Pyridoxal kinase

O01824 Putative pyridoxal kinase

O82616 Putative fructokinase-5

P23060 Protein MAK32

P55264 Adenosine kinase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002173	Carbohydrate/puine kinase, PfkB, conserved site
IPR011611	Carbohydrate/purine kinase
IPR002139	Ribokinase
IPR004625	Pyridoxal phosphate (active vitamin B6) biosynthesis, pyridoxal kinase
IPR001805	Adenosine kinase
	SWISS-MODEL
	PDB Chain
	ModBase
	CATH Domain

Publications Open in usermanual
1.	Sigrell JA, Cameron AD, Jones TA, Mowbray SL. Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8 A resolution: insights into a new family of kinase structures. Structure 6 183-93 1998 [PubMed: 9519409] http://dx.doi.org/10.1016/S0969-2126(98)00020-3

Additional Reading Open in usermanual
	Musayev FN, di Salvo ML, Ko TP, Gandhi AK, Goswami A, Schirch V, Safo MK. Crystal Structure of human pyridoxal kinase: structural basis of M(+) and M(2+) activation. Protein Sci. 16 2007 2184-94 [PubMed: 17766369] http://dx.doi.org/10.1110/ps.073022107
	Mathews II, McMullan D, Miller MD, Canaves JM, Elsliger MA, Floyd R, Grzechnik SK, Jaroszewski L, Klock HE, Koesema E, Kovarik JS, Kreusch A, Kuhn P, McPhillips TM, Morse AT, Quijano K, Rife CL, Schwarzenbacher R, Spraggon G, Stevens RC, van den Bedem H, Weekes D, Wolf G, Hodgson KO, Wooley J, Deacon AM, Godzik A, Lesley SA, Wilson IA. Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution. Proteins 70 2008 603-8 [PubMed: 18004772] http://dx.doi.org/10.1002/prot.21842
	Zhang Y, El Kouni MH, Ealick SE. Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 angstroms resolution. Acta Crystallogr. D Biol. Crystallogr. 62 2006 140-5 [PubMed: 16421444] http://dx.doi.org/10.1107/S090744490503430X
	Muchmore SW, Smith RA, Stewart AO, Cowart MD, Gomtsyan A, Matulenko MA, Yu H, Severin JM, Bhagwat SS, Lee CH, Kowaluk EA, Jarvis MF, Jakob CL. Crystal structures of human adenosine kinase inhibitor complexes reveal two distinct binding modes. J. Med. Chem. 49 2006 6726-31 [PubMed: 17154503] http://dx.doi.org/10.1021/jm060189a
	Zhang Y, El Kouni MH, Ealick SE. Substrate analogs induce an intermediate conformational change in Toxoplasma gondii adenosine kinase. Acta Crystallogr. D Biol. Crystallogr. 63 2007 126-34 [PubMed: 17242506] http://dx.doi.org/10.1107/S0907444906043654

InterPro 23.1