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InterPro: IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal

Protein matches Help

UniProtKB

Matches:

22338 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011545 DNA/RNA_helicase_DEAD/DEAH_N

Secondary

IPR001410

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF00270	DEAD	22338
Signatures in BioMart

InterPro Relationships Help

Parent

IPR014001 DEAD-like helicase, N-terminal

Found in

IPR004576 Transcription-repair coupling factor
IPR004589 DNA helicase, ATP-dependent, RecQ type
IPR004609 DNA helicase, ATP-dependent, RecG
IPR005259 Primosomal protein n
IPR005736 Reverse gyrase
IPR006293 DNA helicase, ATP-dependent, RecQ type, bacterial
IPR016438 RNA helicase, ATP-dependent, SK12/DOB1
IPR017170 Lhr-like ATP-dependent RNA helicase, predicted
IPR018329 DNA helicase, ATP-dependent, RecQ type, N-terminal

Contains

IPR000629 RNA helicase, ATP-dependent, DEAD-box, conserved site

GO Term annotation Help

Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity

InterPro annotation

Entry Details in BioMart

Abstract

Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.

Structural links Help

PDB - click here

SCOP: c.37.1.16 , c.37.1.19

CATH: 3.40.50.300

Database links Help

Enzyme: EC:3.6.1

PANDIT: PF00270

Pfam Clan: CL0008.22

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011545

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O00571 ATP-dependent RNA helicase DDX3X

O01836 ATP-dependent RNA helicase glh-3

O09053 Werner syndrome ATP-dependent helicase homolog

P09052 ATP-dependent RNA helicase vasa

P10081 ATP-dependent RNA helicase eIF4A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR018982	RQC domain
IPR018329	DNA helicase, ATP-dependent, RecQ type, N-terminal
IPR004589	DNA helicase, ATP-dependent, RecQ type
IPR014021	Helicase, superfamily 1/2, ATP-binding domain
IPR012337	Polynucleotidyl transferase, ribonuclease H fold
IPR013084	Zinc finger, CCHC retroviral-type
IPR002121	Helicase/RNase D C-terminal, HRDC domain
IPR001650	DNA/RNA helicase, C-terminal
IPR001878	Zinc finger, CCHC-type
IPR002562	3'-5' exonuclease
IPR000629	RNA helicase, ATP-dependent, DEAD-box, conserved site
IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014014	RNA helicase, DEAD-box type, Q motif
IPR014001	DEAD-like helicase, N-terminal
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Assenmacher N, Wenig K, Lammens A, Hopfner KP. Structural basis for transcription-coupled repair: the N terminus of Mfd resembles UvrB with degenerate ATPase motifs. J. Mol. Biol. 355 2006 675-83 [PubMed: 16309703] http://dx.doi.org/10.1016/j.jmb.2005.10.033
	Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Seraphin B, Le Hir H, Andersen GR. Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. Science 313 2006 1968-72 [PubMed: 16931718] http://dx.doi.org/10.1126/science.1131981
	Bono F, Ebert J, Lorentzen E, Conti E. The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA. Cell 126 2006 713-25 [PubMed: 16923391] http://dx.doi.org/10.1016/j.cell.2006.08.006
	de la Cruz J, Kressler D, Linder P. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem. Sci. 24 1999 192-8 [PubMed: 10322435] http://dx.doi.org/10.1016/S0968-0004(99)01376-6
	Matsui T, Hogetsu K, Usukura J, Sato T, Kumasaka T, Akao Y, Tanaka N. Structural insight of human DEAD-box protein rck/p54 into its substrate recognition with conformational changes. Genes Cells 11 2006 439-52 [PubMed: 16611246] http://dx.doi.org/10.1111/j.1365-2443.2006.00951.x
	Aubourg S, Kreis M, Lecharny A. The DEAD box RNA helicase family in Arabidopsis thaliana. Nucleic Acids Res. 27 1999 628-36 [PubMed: 9862990] http://dx.doi.org/10.1093/nar/27.2.628
	Deaconescu AM, Chambers AL, Smith AJ, Nickels BE, Hochschild A, Savery NJ, Darst SA. Structural basis for bacterial transcription-coupled DNA repair. Cell 124 2006 507-20 [PubMed: 16469698] http://dx.doi.org/10.1016/j.cell.2005.11.045

InterPro 23.1