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InterPro: IPR011496 Beta-N-acetylglucosaminidase

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UniProtKB

Matches:

196 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR011496 Beta-N-acetylglucosaminidase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07555	NAGidase	196
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of both eukaryotic and prokaryotic hyaluronidases. Human Q9HAR0 is expressed during meningioma [1]. Clostridium perfringens, P26831, is involved in pathogenesis and is likely to act on connectivity tissue during gas gangrene [2]. It catalyses the random hydrolysis of 1->4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Structural links Help

PDB - click here

SCOP: c.1.8.10

Database links Help

Enzyme: EC:3.2.1.52

PANDIT: PF07555

Taxonomic coverage Help

Example proteins Help

O60502 Bifunctional protein NCOAT

P26831 Hyaluronoglucosaminidase

Q8VIJ5 Bifunctional protein NCOAT

Q9EQQ9 Bifunctional protein NCOAT

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016134	Cellulosome enzyme, dockerin type I
IPR018247	EF-Hand 1, calcium-binding site
IPR000421	Coagulation factor 5/8 type, C-terminal
IPR011490	Extracellular matrix-binding protein, Ebh
IPR008979	Galactose-binding domain-like
IPR016181	Acyl-CoA N-acyltransferase
IPR011496	Beta-N-acetylglucosaminidase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E. Novel immunogenic antigen homologous to hyaluronidase in meningioma. Hum. Mol. Genet. 7 1859-72 1998 [PubMed: 9811929] http://hmg.oxfordjournals.org/cgi/content/abstract/7/12/1859
2.	Canard B, Garnier T, Saint-Joanis B, Cole ST. Molecular genetic analysis of the nagH gene encoding a hyaluronidase of Clostridium perfringens. Mol. Gen. Genet. 243 215-24 1994 [PubMed: 8177218]

Additional Reading Open in usermanual
	Whitworth GE, Macauley MS, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Greig IR, Vocadlo DJ. Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise. J. Am. Chem. Soc. 129 2007 635-44 [PubMed: 17227027] http://dx.doi.org/10.1021/ja065697o
	Sheldon WL, Macauley MS, Taylor EJ, Robinson CE, Charnock SJ, Davies GJ, Vocadlo DJ, Black GW. Functional analysis of a group A streptococcal glycoside hydrolase Spy1600 from family 84 reveals it is a beta-N-acetylglucosaminidase and not a hyaluronidase. Biochem. J. 399 2006 241-7 [PubMed: 16822234] http://dx.doi.org/10.1042/BJ20060307
	Scaffidi A, Stubbs KA, Dennis RJ, Taylor EJ, Davies GJ, Vocadlo DJ, Stick RV. A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases. Org. Biomol. Chem. 5 2007 3013-9 [PubMed: 17728868] http://dx.doi.org/10.1039/b709681j
	Rao FV, Dorfmueller HC, Villa F, Allwood M, Eggleston IM, van Aalten DM. Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis. EMBO J. 25 2006 1569-78 [PubMed: 16541109] http://dx.doi.org/10.1038/sj.emboj.7601026
	Macauley MS, Bubb AK, Martinez-Fleites C, Davies GJ, Vocadlo DJ. Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance. J. Biol. Chem. 283 2008 34687-95 [PubMed: 18842583] http://dx.doi.org/10.1074/jbc.M804525200
	Yuzwa SA, Macauley MS, Heinonen JE, Shan X, Dennis RJ, He Y, Whitworth GE, Stubbs KA, McEachern EJ, Davies GJ, Vocadlo DJ. A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. Nat. Chem. Biol. 4 2008 483-90 [PubMed: 18587388] http://dx.doi.org/10.1038/nchembio.96

InterPro 23.1