EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR011490 Extracellular matrix-binding protein, Ebh

Protein matches Help

UniProtKB

Matches:

866 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011490 Extracell_matric-bd_Ebh

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF07554	FIVAR	866
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This domain is found in a wide variety of contexts, but mostly occurring in cell wall associated proteins. A lack of conserved catalytic residues suggests that it is a binding domain. From context, possible substrates are hyaluronate or fibronectin. This is further evidenced by [1]. Possibly the exact substrate is N-acetyl glucosamine. Finding it in the same protein as IPR007781 further supports this proposal. It is found in the C-terminal part of O82833, which is removed during maturation [2]. Some of the proteins it is found in (e.g. Q9RL69) are involved in methicillin resistance [3]. The name FIVAR derives from Found In Various Architectures.

Structural links Help

PDB - click here

SCOP: a.8.1.2

Database links Help

PANDIT: PF07554

Blocks: IPB011490

Taxonomic coverage Help

Example proteins Help

P26831 Hyaluronoglucosaminidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR016134	Cellulosome enzyme, dockerin type I
IPR018247	EF-Hand 1, calcium-binding site
IPR000421	Coagulation factor 5/8 type, C-terminal
IPR011490	Extracellular matrix-binding protein, Ebh
IPR008979	Galactose-binding domain-like
IPR011496	Beta-N-acetylglucosaminidase
	SWISS-MODEL
	PDB Chain
	ModBase

Publications Open in usermanual
1.	Williams RJ, Henderson B, Sharp LJ, Nair SP. Identification of a fibronectin-binding protein from Staphylococcus epidermidis. Infect. Immun. 70 6805-10 2002 [PubMed: 12438356] http://dx.doi.org/10.1128/IAI.70.12.6805-6810.2002
2.	Miyake O, Kobayashi E, Nankai H, Hashimoto W, Mikami B, Murata K. Posttranslational processing of polysaccharide lyase: maturation route for gellan lyase in Bacillus sp. GL1. Arch. Biochem. Biophys. 422 211-20 2004 [PubMed: 14759609] http://dx.doi.org/10.1016/j.abb.2003.12.015
3.	Komatsuzawa H, Ohta K, Sugai M, Fujiwara T, Glanzmann P, Berger-BachiB , Suginaka H. Tn551-mediated insertional inactivation of the fmtB gene encoding a cell wall-associated protein abolishes methicillin resistance in Staphylococcus aureus. J. Antimicrob. Chemother. 45 421-31 2000 [PubMed: 10896508] http://dx.doi.org/10.1093/jac/45.4.421

InterPro 23.1