EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR011395 Alpha-glucuronidase

Protein matches Help

UniProtKB

Matches:

99 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011395 Alpha-glucuronds

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF029900	Alpha-glucuronds	99
Signatures in BioMart

InterPro Relationships Help

Contains

IPR005154 Glycoside hydrolase family 67
IPR011099 Glycosyl hydrolase 67, C-terminal
IPR011100 Glycosyl hydrolase 67 middle

GO Term annotation Help

Process

GO:0045493 xylan catabolic process

Function

GO:0046559 alpha-glucuronidase activity

Component

GO:0005576 extracellular region

InterPro annotation

Entry Details in BioMart

Abstract

Alpha-glucuronidases belong to an ensemble of enzymes, which are central to the recycling of photosynthetic biomass. To date, all of the alpha-glucuronidases are classified as family 67 glycosidases, which catalyze the hydrolysis via the investing mechanism [1]. They hydrolyze the alpha1,2-glycosidic bond between 4-O-methyl-d-glucuronic acid (4-O-MeGlcA) and the xylan or xylooligosaccharide backbone [2]. They have three domains, the central of which is a (beta/alpha)(8) barrel, which houses the catalytic apparatus [3]. The carboxylate and methyl groups of aldobiouronic acid can act as substrate recognition determinants [1].

Structural links Help

PDB - click here

SCOP: c.1.8.10 , d.92.2.2

CATH: 3.20.20.80 , 3.30.379.10 , 3.90.1330.10

Database links Help

Enzyme: EC:3.2.1.139

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011395

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O42814 Alpha-glucuronidase

P96105 Alpha-glucuronidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR005154	Glycoside hydrolase family 67
IPR017853	Glycoside hydrolase, catalytic core
IPR011395	Alpha-glucuronidase
IPR011100	Glycosyl hydrolase 67 middle
IPR011099	Glycosyl hydrolase 67, C-terminal
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Golan G, Shallom D, Teplitsky A, Zaide G, Shulami S, Baasov T, Stojanoff V, Thompson A, Shoham Y, Shoham G. Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. J. Biol. Chem. 279 3014-24 2004 [PubMed: 14573597] http://dx.doi.org/10.1074/jbc.M310098200
2.	Nagy T, Nurizzo D, Davies GJ, Biely P, Lakey JH, Bolam DN, Gilbert HJ. The alpha-glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants. J. Biol. Chem. 278 20286-92 2003 [PubMed: 12654910] http://dx.doi.org/10.1074/jbc.M302205200
3.	Nurizzo D, Nagy T, Gilbert HJ, Davies GJ. The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A. Structure 10 547-56 2002 [PubMed: 11937059] http://dx.doi.org/10.1016/S0969-2126(02)00742-6

InterPro 23.1