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InterPro: IPR011099 Glycosyl hydrolase 67, C-terminal

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Matches:

129 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR011099 Glyco_hydro_67_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Gene3D	G3DSA:3.90.1330.10	Glyco_hydro_67_C	119
Pfam	PF07477	Glyco_hydro_67C	129
Signatures in BioMart

InterPro Relationships Help

Found in

IPR011395 Alpha-glucuronidase
IPR017853 Glycoside hydrolase, catalytic core

GO Term annotation Help

Process

GO:0045493 xylan catabolic process

Function

GO:0046559 alpha-glucuronidase activity

Component

GO:0005576 extracellular region

InterPro annotation

Entry Details in BioMart

Abstract

Alpha-glucuronidases, components of an ensemble of enzymes central to the recycling of photosynthetic biomass, remove the alpha-1,2 linked 4-O-methyl glucuronic acid from xylans. This family represents the C-terminal region of alpha-glucuronidase, which is mainly alpha-helical. It wraps around the catalytic domain (IPR011100), making additional interactions both with the N-terminal domain (IPR005154) of its parent monomer and also forming the majority of the dimer-surface with the equivalent C-terminal domain of the other monomer of the dimer [1].

Structural links Help

PDB - click here

SCOP: c.1.8.10

CATH: 3.20.20.80 , 3.90.1330.10

Database links Help

Enzyme: EC:3.2.1.139

PANDIT: PF07477

Blocks: IPB011099

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011099

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O42814 Alpha-glucuronidase

P96105 Alpha-glucuronidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR005154	Glycoside hydrolase family 67
IPR017853	Glycoside hydrolase, catalytic core
IPR011395	Alpha-glucuronidase
IPR011100	Glycosyl hydrolase 67 middle
IPR011099	Glycosyl hydrolase 67, C-terminal
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Nurizzo D, Nagy T, Gilbert HJ, Davies GJ. The structural basis for catalysis and specificity of the Pseudomonas cellulosa alpha-glucuronidase, GlcA67A. Structure 10 547-56 2002 [PubMed: 11937059] http://dx.doi.org/10.1016/S0969-2126(02)00742-6

Additional Reading Open in usermanual
	Nagy T, Nurizzo D, Davies GJ, Biely P, Lakey JH, Bolam DN, Gilbert HJ. The alpha-glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants. J. Biol. Chem. 278 2003 20286-92 [PubMed: 12654910] http://dx.doi.org/10.1074/jbc.M302205200
	Golan G, Shallom D, Teplitsky A, Zaide G, Shulami S, Baasov T, Stojanoff V, Thompson A, Shoham Y, Shoham G. Crystal structures of Geobacillus stearothermophilus alpha-glucuronidase complexed with its substrate and products: mechanistic implications. J. Biol. Chem. 279 2004 3014-24 [PubMed: 14573597] http://dx.doi.org/10.1074/jbc.M310098200

InterPro 23.1