InterPro: IPR011071 Polysaccharide lyase family 8-like, C-terminal

Proteins containing this C-terminal domain consist of a group of secreted bacterial lyase enzymes capable of acting on a variety of substrates. One such enzyme is hyaluronate lyase, a Streptococcal surface enzyme that degrades hyaluronan and chondroitin, thereby helping to spread the bacteria throughout host tissues [1]. Hyaluronate lyase (EC:4.2.2.1) is a four-domain enzyme containing an N-terminal carbohydrate-binding domain, a spacer domain, a catalytic domain, and a C-terminal domain that modulates access to the catalytic cleft of the enzyme. The C-terminal domain has a beta sandwich fold consisting of 10 strands in two sheets. Other bacterial enzymes that display this structure include the C-terminal domain of chondroitin AC lyase (EC:4.2.2.5) [2], the C-terminal domain of chondroitin ABC lyase (EC:4.2.2.4) [3], and the C-terminal domain of xanthan lyase (EC:4.2.2.12) [4]. This entry represents the C-terminal domain of hyaluronate lyase, chondroitin AC lyase, chondroitin ABC lyase and xanthan lyase.