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InterPro: IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase

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UniProtKB

Matches:

2228 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR011041 Quinoprot_gluc/sorb_DH

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF50952	Quino_gluc_DH	2228
Signatures in BioMart

InterPro Relationships Help

Parent

IPR011042 Six-bladed beta-propeller, TolB-like

Children

IPR019893 PQQ-dependent dehydrogenase, s-GDH family

Found in

IPR007788 Glutamine cyclotransferase
IPR011217 Streptogramin lyase
IPR013428 Putative membrane-bound dehydrogenase

Contains

IPR012938 Glucose sorbosone dehydrogenase

GO Term annotation Help

Function

GO:0003824 catalytic activity

InterPro annotation

Entry Details in BioMart

Abstract

Quinoproteins form a class of dehydrogenases distinct from the NAD(P)- and flavin-dependent enzymes, using one of four different quinone cofactors for the oxidation of a variety of compounds. Soluble glucose dehydrogenase (s-GDH) from the bacterium Acinetobacter calcoaceticus is a quinoprotein that requires the cofactor pyrroloquinoline quinone (PQQ) to catalyse the oxidation of glucose to gluconolactone [1]. s-GDH has six 4-stranded beta-sheets in a beta-propeller fold.

Structural links Help

PDB - click here

SCOP: b.68.2.1

CATH: 2.120.10.30

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR011041

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P13650 Quinoprotein glucose dehydrogenase B

P73001 Uncharacterized protein slr1608

Q14DK5 HHIP-like protein 1

Q94F08 HIPL2 protein

Q96QV1 Hedgehog-interacting protein

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019893	PQQ-dependent dehydrogenase, s-GDH family
IPR017448	Speract/scavenger receptor related
IPR013111	EGF, extracellular
IPR006210	EGF-like
IPR012938	Glucose sorbosone dehydrogenase
IPR011042	Six-bladed beta-propeller, TolB-like
IPR011041	Soluble quinoprotein glucose/sorbosone dehydrogenase
IPR001190	Speract/scavenger receptor
IPR000742	EGF-like, type 3
IPR013032	EGF-like region, conserved site
IPR018143	Folate receptor, conserved region
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Oubrie A, Rozeboom HJ, Dijkstra BW. Active-site structure of the soluble quinoprotein glucose dehydrogenase complexed with methylhydrazine: a covalent cofactor-inhibitor complex. Proc. Natl. Acad. Sci. U.S.A. 96 11787-91 1999 [PubMed: 10518528] http://dx.doi.org/10.1073/pnas.96.21.11787

Additional Reading Open in usermanual
	Oubrie A, Rozeboom HJ, Kalk KH, Olsthoorn AJ, Duine JA, Dijkstra BW. Structure and mechanism of soluble quinoprotein glucose dehydrogenase. EMBO J. 18 1999 5187-94 [PubMed: 10508152] http://dx.doi.org/10.1093/emboj/18.19.5187
	Oubrie A, Rozeboom HJ, Kalk KH, Duine JA, Dijkstra BW. The 1.7 A crystal structure of the apo form of the soluble quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus reveals a novel internal conserved sequence repeat. J. Mol. Biol. 289 1999 319-33 [PubMed: 10366508] http://dx.doi.org/10.1006/jmbi.1999.2766

InterPro 23.1