EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR010916 TonB box, conserved site

Protein matches Help

UniProtKB

Matches:

1443 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR010916 TonB_box_CS

Secondary

IPR000531

Type

Conserved_site

Signatures Help

Database	ID	Name	Proteins
PROSITE pattern	PS00430	TONB_DEPENDENT_REC_1	1443
Signatures in BioMart

InterPro Relationships Help

Found in

IPR010101 TonB-dependent vitamin B12 receptor

InterPro annotation

Entry Details in BioMart

Abstract

This entry describes a short conserved region at the N terminus called the tonB-box [1, 2, 3], which is involved in the interaction of the protein with the tonB protein [4]. In Escherichia coli the tonB protein interacts with outer membrane receptor proteins that carry out high-affinity binding and energy-dependent uptake of specific substrates into the periplasmic space. These substrates are either poorly permeable through the porin channels or are encountered at very low concentrations. In the absence of tonB these receptors bind their substrates but do not carry out active transport. The tonB protein also interacts with some colicins.

Structural links Help

PDB - click here

SCOP: f.4.3.3

CATH: 2.170.130.10

Database links Help

PDBe-motif: PS00430

PROSITE doc: PDOC00354

Blocks: IPB010916

Taxonomic coverage Help

Example proteins Help

P01023 Alpha-2-macroglobulin

P05825 Ferrienterobactin receptor

P14046 Alpha-1-inhibitor 3

P28665 Murinoglobulin-1

Q9VCR7 Cystinosin homolog

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
IPR002890	Alpha-2-macroglobulin, N-terminal
IPR008930	Terpenoid cylases/protein prenyltransferase alpha-alpha toroid
IPR001599	Alpha-2-macroglobulin
IPR006603	Cystinosin/ERS1p repeat
IPR019742	Alpha-2-macroglobulin, conserved site
IPR010917	TonB-dependent receptor, conserved site
IPR000531	TonB-dependent receptor, beta-barrel
IPR010916	TonB box, conserved site
IPR010105	TonB-dependent siderophore receptor
IPR005282	Lysosomal cystine transporter
IPR012910	TonB-dependent receptor, plug
IPR009048	Alpha-macroglobulin, receptor-binding
IPR011626	A-macroglobulin complement component
IPR011625	Alpha-2-macroglobulin, N-terminal 2
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Lundrigan MD, Kadner RJ. Nucleotide sequence of the gene for the ferrienterochelin receptor FepA in Escherichia coli. Homology among outer membrane receptors that interact with TonB. J. Biol. Chem. 261 10797-801 1986 [PubMed: 3015941] http://intl.jbc.org/cgi/content/abstract/261/23/10797
2.	Schramm E, Mende J, Braun V, Kamp RM. Nucleotide sequence of the colicin B activity gene cba: consensus pentapeptide among TonB-dependent colicins and receptors. J. Bacteriol. 169 3350-7 1987 [PubMed: 2439491] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=2439491
3.	Nau CD, Konisky J. Evolutionary relationship between the TonB-dependent outer membrane transport proteins: nucleotide and amino acid sequences of the Escherichia coli colicin I receptor gene. J. Bacteriol. 171 1041-7 1989 [PubMed: 2644220] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2644220
4.	Gudmundsdottir A, Bell PE, Lundrigan MD, Bradbeer C, Kadner RJ. Point mutations in a conserved region (TonB box) of Escherichia coli outer membrane protein BtuB affect vitamin B12 transport. J. Bacteriol. 171 6526-33 1989 [PubMed: 2687240] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=2687240

Additional Reading Open in usermanual
	Pawelek PD, Croteau N, Ng-Thow-Hing C, Khursigara CM, Moiseeva N, Allaire M, Coulton JW. Structure of TonB in complex with FhuA, E. coli outer membrane receptor. Science 312 2006 1399-402 [PubMed: 16741125] http://dx.doi.org/10.1126/science.1128057
	Chimento DP, Mohanty AK, Kadner RJ, Wiener MC. Substrate-induced transmembrane signaling in the cobalamin transporter BtuB. Nat. Struct. Biol. 10 2003 394-401 [PubMed: 12652322] http://dx.doi.org/10.1038/nsb914
	Cherezov V, Yamashita E, Liu W, Zhalnina M, Cramer WA, Caffrey M. In meso structure of the cobalamin transporter, BtuB, at 1.95 A resolution. J. Mol. Biol. 364 2006 716-34 [PubMed: 17028020] http://dx.doi.org/10.1016/j.jmb.2006.09.022
	Sharma O, Yamashita E, Zhalnina MV, Zakharov SD, Datsenko KA, Wanner BL, Cramer WA. Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon. J. Biol. Chem. 282 2007 23163-70 [PubMed: 17548346] http://dx.doi.org/10.1074/jbc.M703004200
	Shultis DD, Purdy MD, Banchs CN, Wiener MC. Outer membrane active transport: structure of the BtuB:TonB complex. Science 312 2006 1396-9 [PubMed: 16741124] http://dx.doi.org/10.1126/science.1127694

InterPro 23.1