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InterPro: IPR010723 HemN, C-terminal

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UniProtKB

Matches:

2540 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR010723 HemN_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF06969	HemN_C	2540
Signatures in BioMart

InterPro Relationships Help

Found in

IPR004558 Oxygen-independent coproporphyrinogen III oxidase HemN
IPR004559 Putative oxygen-independent coproporphyrinogen III oxidase

GO Term annotation Help

Process

GO:0006779 porphyrin biosynthetic process
GO:0055114 oxidation reduction

Function

GO:0004109 coproporphyrinogen oxidase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Proteins containing this domain are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This enzyme catalyses the oxygen-independent conversion of coproporphyrinogen-III to protoporphyrinogen-IX [1], one of the last steps in haem biosynthesis. The function of this domain is unclear, but comparison to other proteins containing a radical SAM domain suggest it may be a substrate binding domain.

Structural links Help

PDB - click here

SCOP: c.1.28.2

Database links Help

Enzyme: EC:1.3.99

PANDIT: PF06969

Blocks: IPB010723

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR010723

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A4IGH2 Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

P32131 Oxygen-independent coproporphyrinogen-III oxidase

P73245 Oxygen-independent coproporphyrinogen-III oxidase-like protein sll1917

Q5SUV1 Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

Q9HA92 Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR010723	HemN, C-terminal
IPR007197	Radical SAM
IPR006638	Elongator protein 3/MiaB/NifB
IPR004558	Oxygen-independent coproporphyrinogen III oxidase HemN
IPR004559	Putative oxygen-independent coproporphyrinogen III oxidase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Open in usermanual
1.	Dailey HA. Terminal steps of haem biosynthesis. Biochem. Soc. Trans. 30 590-5 2002 [PubMed: 12196143] http://dx.doi.org/10.1042/BST0300590

Additional Reading Open in usermanual
	Layer G, Moser J, Heinz DW, Jahn D, Schubert WD. Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes. EMBO J. 22 2003 6214-24 [PubMed: 14633981] http://dx.doi.org/10.1093/emboj/cdg598

InterPro 23.1