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InterPro: IPR010300 Cysteine dioxygenase type I

UniProtKB

Matches:

388 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

IPR010300 Cys_dOase_I

Type

Family

Signatures Help

Contains

IPR011051 Cupin, RmlC-type

Process

GO:0046439 L-cysteine metabolic process
GO:0055114 oxidation reduction

Function

GO:0005506 iron ion binding
GO:0017172 cysteine dioxygenase activity

InterPro annotation

Cysteine dioxygenase type I (EC:1.13.11.20) converts cysteine to cysteinesulphinic acid and is the rate-limiting step in sulphate production.

SCOP: b.82.1.19

CATH: 1.20.5.440

Enzyme: EC:1.13.11.20

PANDIT: PF05995

Blocks: IPB010300

O32085 Cysteine dioxygenase

P21816 Cysteine dioxygenase type 1

P60334 Cysteine dioxygenase type 1

Q16878 Cysteine dioxygenase type 1

Q20893 Cysteine dioxygenase

InterPro entry accession number/name and structure databases		Colour code
IPR010300	Cysteine dioxygenase type I
IPR011051	Cupin, RmlC-type
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Additional Reading Open in usermanual
	Levin EJ, Kondrashov DA, Wesenberg GE, Phillips GN Jr. Ensemble refinement of protein crystal structures: validation and application. Structure 15 2007 1040-52 [PubMed: 17850744] http://dx.doi.org/10.1016/j.str.2007.06.019
	Simmons CR, Krishnamoorthy K, Granett SL, Schuller DJ, Dominy JE Jr, Begley TP, Stipanuk MH, Karplus PA. A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry 47 2008 11390-2 [PubMed: 18847220] http://dx.doi.org/10.1021/bi801546n
	Simmons CR, Liu Q, Huang Q, Hao Q, Begley TP, Karplus PA, Stipanuk MH. Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation. J. Biol. Chem. 281 2006 18723-33 [PubMed: 16611640] http://dx.doi.org/10.1074/jbc.M601555200
	McCoy JG, Bailey LJ, Bitto E, Bingman CA, Aceti DJ, Fox BG, Phillips GN Jr. Structure and mechanism of mouse cysteine dioxygenase. Proc. Natl. Acad. Sci. U.S.A. 103 2006 3084-9 [PubMed: 16492780] http://dx.doi.org/10.1073/pnas.0509262103
	Ye S, Wu X, Wei L, Tang D, Sun P, Bartlam M, Rao Z. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J. Biol. Chem. 282 2007 3391-402 [PubMed: 17135237] http://dx.doi.org/10.1074/jbc.M609337200

InterPro 23.1