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InterPro: IPR010116 Anthranilate synthase component I, archaeal

Protein matches Help

UniProtKB

Matches:

51 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR010116 Anthranilate_synth_I_arc

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01820	TrpE-arch	51
Signatures in BioMart

InterPro Relationships Help

Contains

IPR005801 ADC synthase
IPR006805 Anthranilate synthase component I, N-terminal
IPR015890 Chorismate binding, C-terminal
IPR019999 Anthranilate synthase component I, C-terminal

GO Term annotation Help

Process

GO:0000162 tryptophan biosynthetic process

Function

GO:0004049 anthranilate synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

This model represents an archaeal clade of anthranilate synthase component I enzymes. This enzyme (EC:4.1.3.27) is responsible for the first step of tryptophan biosynthesis from chorismate. The Sulfolobus enzyme has been reported to be part of a gene cluster for Trp biosynthesis [1].

Structural links Help

PDB - click here

SCOP: d.161.1.1

CATH: 3.60.120.10

Database links Help

Enzyme: EC:4.1.3.27

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR010116

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

Q06128 Anthranilate synthase component 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR019999	Anthranilate synthase component I, C-terminal
IPR010116	Anthranilate synthase component I, archaeal
IPR005801	ADC synthase
IPR006805	Anthranilate synthase component I, N-terminal
IPR015890	Chorismate binding, C-terminal
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Tutino ML, Scarano G, Marino G, Sannia G, Cubellis MV. Tryptophan biosynthesis genes trpEGC in the thermoacidophilic archaebacterium Sulfolobus solfataricus. J. Bacteriol. 175 299-302 1993 [PubMed: 8416906] http://jb.asm.org/cgi/content/abstract/175/1/299

Additional Reading Open in usermanual
	Knochel T, Ivens A, Hester G, Gonzalez A, Bauerle R, Wilmanns M, Kirschner K, Jansonius JN. The crystal structure of anthranilate synthase from Sulfolobus solfataricus: functional implications. Proc. Natl. Acad. Sci. U.S.A. 96 1999 9479-84 [PubMed: 10449718] http://dx.doi.org/10.1073/pnas.96.17.9479

InterPro 23.1