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InterPro: IPR010074 Phosphoribosylformylglycinamidine synthase II

Protein matches Help

UniProtKB

Matches:

789 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR010074 PRibForGlyAmidine_synth_II

Type

Family

Signatures Help

Database	ID	Name	Proteins
TIGRFAMs	TIGR01736	FGAM_synth_II	789
Signatures in BioMart

InterPro Relationships Help

Contains

IPR000728 AIR synthase related protein
IPR010918 AIR synthase related protein, C-terminal

GO Term annotation Help

Process

GO:0006189 'de novo' IMP biosynthetic process

Function

GO:0004642 phosphoribosylformylglycinamidine synthase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

Phosphoribosylformylglycinamidine synthase is a single, long polypeptide in most bacteria. Three proteins are required in Bacillus subtilis and many other species. This is the longest of the three and is designated PurL, phosphoribosylformylglycinamidine synthase II, or FGAM synthase II.

Structural links Help

PDB - click here

SCOP: d.139.1.1 , d.79.4.1

Database links Help

Enzyme: EC:6.3.5.3

CluSTr: ALLvsALL:43635:83.7

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR010074

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

A0B5C7 Phosphoribosylformylglycinamidine synthase 2

A2BNC9 Phosphoribosylformylglycinamidine synthase 2

P72644 Phosphoribosylformylglycinamidine synthase 2

Q9X0X3 Phosphoribosylformylglycinamidine synthase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR010074	Phosphoribosylformylglycinamidine synthase II
IPR010918	AIR synthase related protein, C-terminal
IPR000728	AIR synthase related protein
IPR016188	PurM, N-terminal-like
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain

Publications Help

Additional Reading Open in usermanual
	Mathews II, Krishna SS, Schwarzenbacher R, McMullan D, Abdubek P, Ambing E, Canaves JM, Chiu HJ, Deacon AM, DiDonato M, Elsliger MA, Godzik A, Grittini C, Grzechnik SK, Hale J, Hampton E, Han GW, Haugen J, Jaroszewski L, Klock HE, Koesema E, Kreusch A, Kuhn P, Lesley SA, Levin I, Miller MD, Moy K, Nigoghossian E, Paulsen J, Quijano K, Reyes R, Spraggon G, Stevens RC, van den Bedem H, Velasquez J, White A, Wolf G, Xu Q, Hodgson KO, Wooley J, Wilson IA. Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. Proteins 63 2006 1106-11 [PubMed: 16544324] http://dx.doi.org/10.1002/prot.20650
	Morar M, Hoskins AA, Stubbe J, Ealick SE. Formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima: structural insights into complex formation. Biochemistry 47 2008 7816-30 [PubMed: 18597481] http://dx.doi.org/10.1021/bi800329p
	Sampei G, Mizobuchi K. The organization of the purL gene encoding 5'-phosphoribosylformylglycinamide amidotransferase of Escherichia coli. J. Biol. Chem. 264 1989 21230-8 [PubMed: 2531746] http://intl.jbc.org/cgi/content/abstract/264/35/21230
	Morar M, Anand R, Hoskins AA, Stubbe J, Ealick SE. Complexed structures of formylglycinamide ribonucleotide amidotransferase from Thermotoga maritima describe a novel ATP binding protein superfamily. Biochemistry 45 2006 14880-95 [PubMed: 17154526] http://dx.doi.org/10.1021/bi061591u

InterPro 23.1