InterPro: IPR010000 Caerin 1

This family consists of several caerin 1 proteins from Litoria species, Australian tree frogs. The caerin 1 peptides are among the most powerful of the broad-spectrum antibiotic amphibian peptides [1]. These peptides are excreted from amphibian skin, and can interact with and disrupt bacterial membranes, leading to the permeabilisation of the cell membrane. Caerin 1.1 forms a helix-bend-helix sturcture, where both helices are required for activity, as well as the bend region for flexibility.