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InterPro: IPR008979 Galactose-binding domain-like

Protein matches Help

UniProtKB

Matches:

12614 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008979 Galactose-bd-like

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF49785	Gal_bind_like	12614
Signatures in BioMart

InterPro Relationships Help

Children

IPR000421 Coagulation factor 5/8 type, C-terminal
IPR001090 Ephrin receptor, ligand binding
IPR002706 DNA-repair protein Xrcc1, N-terminal
IPR003305 Carbohydrate-binding, CenC-like
IPR005084 Carbohydrate binding domain, family 6
IPR005086 Carbohydrate binding domain, family 17/28
IPR005088 Carbohydrate binding domain, family 15
IPR005638 Delta endotoxin, C-terminal
IPR006104 Glycoside hydrolase family 2, carbohydrate-binding
IPR010565 Muskelin, N-terminal
IPR012919 Sad1/UNC-like, C-terminal
IPR013736 Peptidase S15/CocE/NonD, C-terminal
IPR015176 Lyase, N-terminal
IPR015295 Carbohydrate binding module 27
IPR015908 Allantoicase domain

Found in

IPR001944 Glycoside hydrolase, family 35
IPR004939 Anaphase-promoting complex, subunit 10
IPR006585 Fucolectin tachylectin-4 pentraxin-1
IPR010900 Nicotine adenine dinucleotide glycohydrolase
IPR012905 PA-IL-like
IPR016257 Tyrosine-protein kinase, ephrin receptor
IPR016590 Rhamnogalacturonase B
IPR016625 Uncharacterised conserved protein UCP014872, subtilisin-related
IPR016901 Anaphase-promoting complex, subunit 10, subgroup
IPR017313 Peptidase S8A, subtilisin-related, clostridia-2
IPR017319 Peptidase S8A, subtilisin-related, prokarya
IPR017323 Lysyl endopeptidase
IPR020694 Tyrosine-protein kinase, ephrin receptor, subgroup
IPR020742 Tyrosine-protein kinase, discoidin domain-containing receptor
IPR020766 Tyrosine-protein kinase, ephrin A10 receptor
IPR020767 Tyrosine-protein kinase, ephrin B6 receptor
IPR020768 Tyrosine-protein kinase, ephrin A receptor
IPR020769 Tyrosine-protein kinase, ephrin B receptor
IPR020770 Tyrosine-protein kinase, ephrin A1/A2 receptor

Contains

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site

InterPro annotation

Entry Details in BioMart

Abstract

Proteins containing a galactose-binding domain-like fold can be found in several different protein families, in both eukaryotes and prokaryotes. The common function of these domains is to bind to specific ligands, such as cell-surface-attached carbohydrate substrates for galactose oxidase and sialidase [1], phospholipids on the outer side of the mammalian cell membrane for coagulation factor Va [2], membrane-anchored ephrin for the Eph family of receptor tyrosine kinases [3], and a complex of broken single-stranded DNA and DNA polymerase beta for XRCC1 [4].

The structure of the galactose-binding domain-like members consists of a beta-sandwich, in which the strands making up the sheets exhibit a jellyroll fold. There is a high degree of similarity in the beta-sandwich and in the loops between different family members, despite an often low level of sequence similarity.

Structural links Help

PDB - click here

SCOP: a.246.1.1 , b.1.18.2 , b.1.4.1 , b.18.1.1 , b.18.1.10 , b.18.1.11 , b.18.1.12 , b.18.1.13 , b.18.1.14 , b.18.1.15 , b.18.1.16 , b.18.1.17 , b.18.1.18 , b.18.1.19 , b.18.1.2 , b.18.1.20 , b.18.1.21 , b.18.1.22 , b.18.1.23 , b.18.1.24 , b.18.1.25 , b.18.1.28 , b.18.1.3 , b.18.1.4 , b.18.1.5 , b.18.1.7 , b.18.1.8 , b.18.1.9 , c.1.8.3 , c.69.1.21 , j.13.1.1

CATH: 2.60.120.260 , 2.60.120.360 , 2.60.120.380 , 2.60.120.410 , 2.60.120.430 , 3.20.20.80 , 3.40.50.1820

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR008979

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O14786 Neuropilin-1

O61460 Ephrin receptor 1

P13134 Kexin

P19137 Laminin subunit alpha-1

P26016 Furin-like protease 1, isoforms 1/1-X/2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR018031	Laminin B, subgroup
IPR001791	Laminin G
IPR000421	Coagulation factor 5/8 type, C-terminal
IPR000998	MAM
IPR017441	Protein kinase, ATP binding site
IPR000859	CUB
IPR000209	Peptidase S8/S53, subtilisin/kexin/sedolisin
IPR009030	Growth factor, receptor
IPR002884	Proprotein convertase, P
IPR009020	Proteinase inhibitor, propeptide
IPR011009	Protein kinase-like domain
IPR008957	Fibronectin, type III-like fold
IPR008979	Galactose-binding domain-like
IPR000719	Protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR010307	Laminin II
IPR008211	Laminin, N-terminal
IPR013032	EGF-like region, conserved site
IPR003961	Fibronectin, type III
IPR014648	Neuropilin
IPR009254	Laminin I
IPR013320	Concanavalin A-like lectin/glucanase, subgroup
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR002049	EGF-like, laminin
IPR012679	Laminin G, subdomain 1
IPR001090	Ephrin receptor, ligand binding
IPR020685	Tyrosine-protein kinase
IPR015500	Peptidase S8, subtilisin-related
IPR000034	Laminin B type IV
IPR008985	Concanavalin A-like lectin/glucanase
	ModBase
	SWISS-MODEL
	PDB Chain
	CATH Domain
	SCOP Domain

Publications Open in usermanual
1.	Ito N, Phillips SE, Stevens C, Ogel ZB, McPherson MJ, Keen JN, Yadav KD, Knowles PF. Novel thioether bond revealed by a 1.7 A crystal structure of galactose oxidase. Nature 350 87-90 1991 [PubMed: 2002850] http://dx.doi.org/10.1038/350087a0
2.	Macedo-Ribeiro S, Bode W, Huber R, Quinn-Allen MA, Kim SW, Ortel TL, Bourenkov GP, Bartunik HD, Stubbs MT, Kane WH, Fuentes-Prior P. Crystal structures of the membrane-binding C2 domain of human coagulation factor V. Nature 402 434-9 1999 [PubMed: 10586886] http://dx.doi.org/10.1038/46594
3.	Himanen JP, Rajashankar KR, Lackmann M, Cowan CA, Henkemeyer M, Nikolov DB. Crystal structure of an Eph receptor-ephrin complex. Nature 414 933-8 2001 [PubMed: 11780069] http://dx.doi.org/10.1038/414933a
4.	Marintchev A, Mullen MA, Maciejewski MW, Pan B, Gryk MR, Mullen GP. Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat. Struct. Biol. 6 884-93 1999 [PubMed: 10467102] http://dx.doi.org/10.1038/12347

Additional Reading Open in usermanual
	Shao C, Novakovic VA, Head JF, Seaton BA, Gilbert GE. Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif. J. Biol. Chem. 283 2008 7230-41 [PubMed: 18160406] http://dx.doi.org/10.1074/jbc.M705195200
	Ramelot TA, Raman S, Kuzin AP, Xiao R, Ma LC, Acton TB, Hunt JF, Montelione GT, Baker D, Kennedy MA. Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study. Proteins 75 2009 147-67 [PubMed: 18816799] http://dx.doi.org/10.1002/prot.22229
	Tailford LE, Offen WA, Smith NL, Dumon C, Morland C, Gratien J, Heck MP, Stick RV, Bleriot Y, Vasella A, Gilbert HJ, Davies GJ. Structural and biochemical evidence for a boat-like transition state in beta-mannosidases. Nat. Chem. Biol. 4 2008 306-12 [PubMed: 18408714] http://dx.doi.org/10.1038/nchembio.81
	Rogers MS, Hurtado-Guerrero R, Firbank SJ, Halcrow MA, Dooley DM, Phillips SE, Knowles PF, McPherson MJ. Cross-link formation of the cysteine 228-tyrosine 272 catalytic cofactor of galactose oxidase does not require dioxygen. Biochemistry 47 2008 10428-39 [PubMed: 18771294] http://dx.doi.org/10.1021/bi8010835
	Blanchard B, Nurisso A, Hollville E, Tetaud C, Wiels J, Pokorna M, Wimmerova M, Varrot A, Imberty A. Structural basis of the preferential binding for globo-series glycosphingolipids displayed by Pseudomonas aeruginosa lectin I. J. Mol. Biol. 383 2008 837-53 [PubMed: 18762193] http://dx.doi.org/10.1016/j.jmb.2008.08.028

InterPro 23.1