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InterPro: IPR008965 Carbohydrate-binding

Protein matches Help

UniProtKB

Matches:

1358 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008965 Carb_bd

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF49384	Cellul_bind	1358
Signatures in BioMart

InterPro Relationships Help

Children

IPR001956 Bacterial type 3a, cellulose-binding
IPR002102 Cellulosome anchoring protein, cohesin domain
IPR012291 Cellulose-binding family II/chitobiase, carbohydrate-binding domain

Contains

IPR018366 Carbohydrate-binding type-2, conserved site
IPR019028 Carbohydrate binding domain CBM49

GO Term annotation Help

Function

GO:0030246 carbohydrate binding

InterPro annotation

Entry Details in BioMart

Abstract

This carbohydrate-binding domain is found in a number of proteins, for example the N-terminal domain of the chitobiase/beta-hexosaminidase family of glycoside hydrolases, the carbohydrate-binding domain of bacterial cellulases and xylanases, and the cellulose-binding domain of bacterial proteins such as scafoldin, cellobiose and cohesin. The carbohydrate-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology and is a sub-class of the immunoglobin-like fold [1].

Structural links Help

PDB - click here

SCOP: b.2.2.1 , b.2.2.2 , b.2.2.3

CATH: 2.60.40.290 , 2.60.40.680 , 2.60.40.710

Database links Help

Enzyme: EC:3.2.1

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR008965

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P07986 Exoglucanase/xylanase

P08797 Stalk-specific protein A

Q42059 Endoglucanase 6

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR013781	Glycoside hydrolase, subgroup, catalytic core
IPR001701	Glycoside hydrolase, family 9
IPR012291	Cellulose-binding family II/chitobiase, carbohydrate-binding domain
IPR019028	Carbohydrate binding domain CBM49
IPR012341	Six-hairpin glycosidase
IPR008965	Carbohydrate-binding
IPR001000	Glycoside hydrolase, family 10
IPR008928	Six-hairpin glycosidase-like
IPR017853	Glycoside hydrolase, catalytic core
IPR001919	Cellulose-binding domain, family II, bacterial type
IPR018221	Glycoside hydrolase, family 9, active site
IPR018366	Carbohydrate-binding type-2, conserved site
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Tormo J, Lamed R, Chirino AJ, Morag E, Bayer EA, Shoham Y, Steitz TA. Crystal structure of a bacterial family-III cellulose-binding domain: a general mechanism for attachment to cellulose. EMBO J. 15 5739-51 1996 [PubMed: 8918451] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=8918451

Additional Reading Open in usermanual
	Carvalho AL, Dias FM, Nagy T, Prates JA, Proctor MR, Smith N, Bayer EA, Davies GJ, Ferreira LM, Romao MJ, Fontes CM, Gilbert HJ. Evidence for a dual binding mode of dockerin modules to cohesins. Proc. Natl. Acad. Sci. U.S.A. 104 2007 3089-94 [PubMed: 17360613] http://dx.doi.org/10.1073/pnas.0611173104
	Adams JJ, Pal G, Jia Z, Smith SP. Mechanism of bacterial cell-surface attachment revealed by the structure of cellulosomal type II cohesin-dockerin complex. Proc. Natl. Acad. Sci. U.S.A. 103 2006 305-10 [PubMed: 16384918] http://dx.doi.org/10.1073/pnas.0507109103
	Noach I, Frolow F, Jakoby H, Rosenheck S, Shimon LW, Lamed R, Bayer EA. Crystal structure of a type-II cohesin module from the Bacteroides cellulosolvens cellulosome reveals novel and distinctive secondary structural elements. J. Mol. Biol. 348 2005 1-12 [PubMed: 15808849] http://dx.doi.org/10.1016/j.jmb.2005.02.024
	Noach I, Frolow F, Alber O, Lamed R, Shimon LJ, Bayer EA. Intermodular linker flexibility revealed from crystal structures of adjacent cellulosomal cohesins of Acetivibrio cellulolyticus. J. Mol. Biol. 391 2009 86-97 [PubMed: 19501595]
	Pinheiro BA, Proctor MR, Martinez-Fleites C, Prates JA, Money VA, Davies GJ, Bayer EA, Fontesm CM, Fierobe HP, Gilbert HJ. The Clostridium cellulolyticum dockerin displays a dual binding mode for its cohesin partner. J. Biol. Chem. 283 2008 18422-30 [PubMed: 18445585] http://dx.doi.org/10.1074/jbc.M801533200

InterPro 23.1