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InterPro: IPR008929 Chondroitin AC/alginate lyase

Protein matches Help

UniProtKB

Matches:

790 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008929 Chondroitin_lyas

Type

Domain

Signatures Help

Database	ID	Name	Proteins
SuperFamily	SSF48230	Chondroitin_lyas	790
Signatures in BioMart

InterPro Relationships Help

Children

IPR012329 Polysaccharide lyase family 8, N-terminal

Found in

IPR006934 Baculovirus occlusion-derived virus envelope, E66
IPR008397 Alginate lyase

InterPro annotation

Entry Details in BioMart

Abstract

Glycosaminoglycans (GAGs) are highly negatively charged polysaccharides, formed from disaccharide repeating units. For a number of bacterial species, including Flavobacterium heparinum synthesize GAG lyases, these enzymes are used to degrade and utilise glycosaminoglycans as a source of carbon in the bacterium's natural environment. In topological terms, the known structures of polysaccharide lyases fall within two protein fold families. Pectin and pectate lyases, as well as chondroitin lyase B belong to the right-handed parallel beta-helix family and have the substrate-binding site in roughly the same topological location. The second topological family, all of which contain a domain consisting of an incomplete (alpha/alpha)5 toroid, includes chondroitin AC lyase family, and alginate lyase A1-III family from Sphingomonas species A1 [1].

Structural links Help

PDB - click here

SCOP: a.102.3.1 , a.102.3.2

CATH: 1.50.10.100 , 1.50.10.110

Database links Help

Enzyme: EC:4.2.2

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR008929

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

O10305 Occlusion-derived virus envelope protein E66

P59807 Chondroitin ABC endolyase 1

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR014718	Glycoside hydrolase-type carbohydrate-binding, subgroup
IPR012329	Polysaccharide lyase family 8, N-terminal
IPR004103	Polysaccharide lyase family 8, C-terminal
IPR011013	Glycoside hydrolase-type carbohydrate-binding
IPR008929	Chondroitin AC/alginate lyase
IPR011071	Polysaccharide lyase family 8-like, C-terminal
IPR015177	Lyase, catalytic
IPR008979	Galactose-binding domain-like
IPR015176	Lyase, N-terminal
IPR003159	Polysaccharide lyase family 8, central domain
IPR006934	Baculovirus occlusion-derived virus envelope, E66
	PDB Chain
	ModBase
	CATH Domain
	SWISS-MODEL
	SCOP Domain

Publications Open in usermanual
1.	Huang W, Boju L, Tkalec L, Su H, Yang HO, Gunay NS, Linhardt RJ, Kim YS, Matte A, Cygler M. Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis. Biochemistry 40 2359-72 2001 [PubMed: 11327856] http://dx.doi.org/10.1021/bi0024254

Additional Reading Open in usermanual
	Maruyama Y, Mikami B, Hashimoto W, Murata K. A structural factor responsible for substrate recognition by Bacillus sp. GL1 xanthan lyase that acts specifically on pyruvated side chains of xanthan. Biochemistry 46 2007 781-91 [PubMed: 17223699] http://dx.doi.org/10.1021/bi0619775
	Rigden DJ, Littlejohn JE, Joshi HV, de Groot BL, Jedrzejas MJ. Alternate structural conformations of Streptococcus pneumoniae hyaluronan lyase: insights into enzyme flexibility and underlying molecular mechanism of action. J. Mol. Biol. 358 2006 1165-78 [PubMed: 16569416] http://dx.doi.org/10.1016/j.jmb.2006.02.066
	Lunin VV, Li Y, Linhardt RJ, Miyazono H, Kyogashima M, Kaneko T, Bell AW, Cygler M. High-resolution crystal structure of Arthrobacter aurescens chondroitin AC lyase: an enzyme-substrate complex defines the catalytic mechanism. J. Mol. Biol. 337 2004 367-86 [PubMed: 15003453] http://dx.doi.org/10.1016/j.jmb.2003.12.071
	Rigden DJ, Botzki A, Nukui M, Mewbourne RB, Lamani E, Braun S, von Angerer E, Bernhardt G, Dove S, Buschauer A, Jedrzejas MJ. Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole. Glycobiology 16 2006 757-65 [PubMed: 16638841] http://dx.doi.org/10.1093/glycob/cwj116
	Maruyama Y, Hashimoto W, Mikami B, Murata K. Crystal structure of Bacillus sp. GL1 xanthan lyase complexed with a substrate: insights into the enzyme reaction mechanism. J. Mol. Biol. 350 2005 974-86 [PubMed: 15979090] http://dx.doi.org/10.1016/j.jmb.2005.05.055

InterPro 23.1