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InterPro: IPR008901 Alkaline phytoceramidase

Protein matches Help

UniProtKB

Matches:

188 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008901 APHC

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05875	aPHC	188
Signatures in BioMart

GO Term annotation Help

Process

GO:0006672 ceramide metabolic process

Function

GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Component

GO:0000139 Golgi membrane
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of several eukaryotic alkaline phytoceramidase (aPHC) sequences. Ceramidases are enzymes involved in regulating cellular levels of ceramides, sphingoid bases, and their phosphates. Alkaline phytoceramidase is responsible for the hydrolysis of phytoceramide [1].

Database links Help

Enzyme: EC:3.5.1

PANDIT: PF05875

Blocks: IPB008901

Taxonomic coverage Help

Example proteins Help

O45145 Alkaline ceramidase

P38298 Alkaline ceramidase YPC1

Q5QJU3 Alkaline ceramidase 2

Q8R4X1 Alkaline ceramidase 1

Q9VIP7 Alkaline ceramidase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008901	Alkaline phytoceramidase
	ModBase

Publications Open in usermanual
1.	Mao C, Xu R, Szulc ZM, Bielawska A, Galadari SH, Obeid LM. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J. Biol. Chem. 276 26577-88 2001 [PubMed: 11356846] http://dx.doi.org/10.1074/jbc.M102818200

InterPro 23.1