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InterPro: IPR008631 Glycogen synthase

Protein matches Help

UniProtKB

Matches:

210 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
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Accession

IPR008631 Glycogen_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05693	Glycogen_syn	206
PANTHER	PTHR10176	Glycogen_synth	197
Signatures in BioMart

GO Term annotation Help

Process

GO:0005978 glycogen biosynthetic process

Function

GO:0004373 glycogen (starch) synthase activity

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of the eukaryotic glycogen synthase proteins GYS1, GYS2 and GYS3. Glycogen synthase (GS) is the enzyme responsible for the synthesis of -1,4-linked glucose chains in glycogen. It is the rate limiting enzyme in the synthesis of the polysaccharide, and its activity is highly regulated through phosphorylation at multiple sites and also by allosteric effectors, mainly glucose 6-phosphate (G6P) [1].

Database links Help

Enzyme: EC:2.4.1.11

PANDIT: PF05693

Blocks: IPB008631

Pfam Clan: CL0113.9

Taxonomic coverage Help

Example proteins Help

P13807 Glycogen [starch] synthase, muscle

P23337 Glycogen [starch] synthase isoform 1

Q8VCB3 Glycogen [starch] synthase, liver

Q9U2D9 Probable glycogen [starch] synthase

Q9VFC8 Putative glycogen [starch] synthase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR008631	Glycogen synthase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Garcia-Rocha M, Roca A, De La Iglesia N, Baba O, Fernandez-Novell JM, Ferrer JC, Guinovart JJ. Intracellular distribution of glycogen synthase and glycogen in primary cultured rat hepatocytes. Biochem. J. 357 17-24 2001 [PubMed: 11415431] http://dx.doi.org/10.1042/0264-6021:3570017

Additional Reading Open in usermanual
	Farkas I, Hardy TA, Goebl MG, Roach PJ. Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled. J. Biol. Chem. 266 1991 15602-7 [PubMed: 1908457] http://intl.jbc.org/cgi/content/abstract/266/24/15602
	Orho M, Bosshard NU, Buist NR, Gitzelmann R, Aynsley-Green A, Blumel P, Gannon MC, Nuttall FQ, Groop LC. Mutations in the liver glycogen synthase gene in children with hypoglycemia due to glycogen storage disease type 0. J. Clin. Invest. 102 1998 507-15 [PubMed: 9691087] http://www.jci.org/cgi/reprint/102/3/507.pdf

InterPro 23.1