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InterPro: IPR008428 Chondroitin N-acetylgalactosaminyltransferase

Protein matches Help

UniProtKB

Matches:

194 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008428 Chond_GalNAc

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05679	CHGN	154
PANTHER	PTHR12369	CHGN	189
Signatures in BioMart

GO Term annotation Help

Function

GO:0016758 transferase activity, transferring hexosyl groups

Component

GO:0032580 Golgi cisterna membrane

InterPro annotation

Entry Details in BioMart

Abstract

This family represents Chondroitin N-acetylgalactosaminyltransferase. Proteins have a type II transmembrane topology. The enzyme is involved in the biosynthetic initiation and elongation of chondroitin sulphate and is the key enzyme responsible for the selective chain assembly of chondroitin/dermatan sulphate on the linkage region tetrasaccharide common to various proteoglycans containing chondroitin/dermatan sulphate or heparin/heparan sulphate chains.

Database links Help

Enzyme: EC:2.4.1

PANDIT: PF05679

Taxonomic coverage Help

Example proteins Help

P45895 Chondroitin sulfate synthase 2

Q5DTK1 Chondroitin sulfate synthase 3

Q6L9W6 N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR011658	PA14
IPR008428	Chondroitin N-acetylgalactosaminyltransferase
	SWISS-MODEL
	ModBase

Publications Help

Additional Reading Open in usermanual
	Uyama T, Kitagawa H, Tamura Ji J, Sugahara K. Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate. J. Biol. Chem. 277 2002 8841-6 [PubMed: 11788602] http://dx.doi.org/10.1074/jbc.M111434200
	Kitagawa H, Uyama T, Sugahara K. Molecular cloning and expression of a human chondroitin synthase. J. Biol. Chem. 276 2001 38721-6 [PubMed: 11514575] http://dx.doi.org/10.1074/jbc.M106871200

InterPro 23.1