EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR008219 Proline dehydrogenase, predicted

Protein matches Help

UniProtKB

Matches:

287 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR008219 Proline_DH_prd

Type

Family

Signatures Help

Database	ID	Name	Proteins
PIRSF	PIRSF000196	Pro_dehydrog	287
Signatures in BioMart

InterPro Relationships Help

Contains

IPR002872 Proline dehydrogenase

GO Term annotation Help

Process

GO:0055114 oxidation reduction

Function

GO:0004657 proline dehydrogenase activity

InterPro annotation

Entry Details in BioMart

Abstract

Proline can be oxidized to glutamate via a two-step process. Proline dehydrogenase (proline oxidase) performs the first step. The second step is performed by delta-1-pyrroline 5-carboxylate dehydrogenase (EC:1.5.1.12), which is often linked to proline dehydrogenase (EC:1.5.99.8) in bifunctional bacterial enzymes such as PutA (IPR011350). The enzymes in this group are predicted to have proline dehydrogenase (PDH) function only, and in this respect are similar to yeast Put1p and other mitochondrial PDHs.

Database links Help

Enzyme: EC:1.5.99.8

Taxonomic coverage Help