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InterPro: IPR008044 Bacteriophage peptidoglycan hydrolase

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UniProtKB

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85 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession

IPR008044 Phage_PGN_hydro

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05382	Amidase_5	85
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

At least one of the members of this domain, the Pal protein from the pneumococcal bacteriophage Dp-1 O03979 has been shown to be an N-acetylmuramoyl-L-alanine amidase [1]. According to the known modular structure of this and other peptidoglycan hydrolases from the pneumococcal system, the active site should reside in the N-terminal domain whereas the C-terminal domain binds to the choline residues of the cell wall teichoic acids [2, 3].

Database links Help

PANDIT: PF05382

Pfam Clan: CL0125.11

Taxonomic coverage Help

Example proteins Help

O03979 Lysin

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR002479	Putative cell wall binding repeat
IPR018337	Cell wall/choline-binding repeat
IPR008044	Bacteriophage peptidoglycan hydrolase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Garcia P, Mendez E, Garcia E, Ronda C, Lopez R. Biochemical characterization of a murein hydrolase induced by bacteriophage Dp-1 in Streptococcus pneumoniae: comparative study between bacteriophage-associated lysin and the host amidase. J. Bacteriol. 159 793-6 1984 [PubMed: 6146601] http://ukpmc.ac.uk/articlerender.cgi?tool=EBI&pubmedid=6146601
2.	Sheehan MM, Garcia JL, Lopez R, Garcia P. The lytic enzyme of the pneumococcal phage Dp-1: a chimeric lysin of intergeneric origin. Mol. Microbiol. 25 717-25 1997 [PubMed: 9379901] http://dx.doi.org/10.1046/j.1365-2958.1997.5101880.x
3.	Garcia E, Garcia JL, Garcia P, Arraras A, Sanchez-Puelles JM, Lopez R. Molecular evolution of lytic enzymes of Streptococcus pneumoniae and its bacteriophages. Proc. Natl. Acad. Sci. U.S.A. 85 914-8 1988 [PubMed: 3422470] http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=EBI&pubmedid=3422470

InterPro 23.1