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InterPro: IPR007991 RNA polymerase I specific transcription initiation factor RRN3

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156 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Accession List
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Accession

IPR007991 RNA_pol_I_trans_ini_fac_RRN3

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05327	RRN3	151
PANTHER	PTHR12790	RNApolI_tif_RRN3	151
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

This family consists of several eukaryotic proteins which are homologous to the Saccharomyces cerevisiae RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in the S. cerevisiae [1] RNA polymerase I complex within the nucleolus. In mammalian cells, the phosphorylation state of Rrn3 regulates rDNA transcription by determining the steady-state concentration of the Rrn3 [2].

Database links Help

PANDIT: PF05327

Blocks: IPB007991

Taxonomic coverage Help

Example proteins Help

A6NIE6 RRN3-like protein 1

B2RS91 RNA polymerase I-specific transcription initiation factor RRN3

P36070 RNA polymerase I-specific transcription initiation factor RRN3

P48322 Uncharacterized protein C36E8.1

Q5R4N9 RNA polymerase I-specific transcription initiation factor RRN3

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007991	RNA polymerase I specific transcription initiation factor RRN3
	ModBase

Publications Open in usermanual
1.	Yamamoto RT, Nogi Y, Dodd JA, Nomura M. RRN3 gene of Saccharomyces cerevisiae encodes an essential RNA polymerase I transcription factor which interacts with the polymerase independently of DNA template. EMBO J. 15 3964-73 1996 [PubMed: 8670901] http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8670901&action=stream&blobtype=pdf
2.	Cavanaugh AH, Hirschler-Laszkiewicz I, Hu Q, Dundr M, Smink T, Misteli T, Rothblum LI. Rrn3 phosphorylation is a regulatory checkpoint for ribosome biogenesis. J. Biol. Chem. 277 27423-32 2002 [PubMed: 12015311] http://dx.doi.org/10.1074/jbc.M201232200

InterPro 23.1