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InterPro: IPR007873 Glycosyltransferase, ALG3

Protein matches Help

UniProtKB

Matches:

149 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007873 Glycosyltransferase_ALG3

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05208	ALG3	149
PANTHER	PTHR12646	ALG3	147
Signatures in BioMart

GO Term annotation Help

Function

GO:0016758 transferase activity, transferring hexosyl groups

Component

GO:0005783 endoplasmic reticulum
GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl pyrophosphate. Whereas early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-Dol to Man9GlcNAc2-PP-Dol on the lumenal side use Dol-P-Man [1]. The ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase.

Database links Help

Enzyme: EC:2.4.1.130

PANDIT: PF05208

Blocks: IPB007873

Pfam Clan: CL0111.7

Taxonomic coverage Help

Example proteins Help

P38179 Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase

P82149 Lethal(2)neighbour of tid protein 2

Q24332 Lethal(2)neighbour of Tid protein

Q8K2A8 Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase

Q92685 Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007873	Glycosyltransferase, ALG3
	ModBase

Publications Open in usermanual
1.	Sharma CB, Knauer R, Lehle L. Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man:Man5GlcNAc2-PP-Dol mannosyltransferase. Biol. Chem. 382 321-8 2001 [PubMed: 11308030] http://dx.doi.org/10.1515/BC.2001.039

Additional Reading Open in usermanual
	Korner C, Knauer R, Stephani U, Marquardt T, Lehle L, von Figura K. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. EMBO J. 18 1999 6816-22 [PubMed: 10581255] http://dx.doi.org/10.1093/emboj/18.23.6816
	Aebi M, Gassenhuber J, Domdey H, te Heesen S. Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology 6 1996 439-44 [PubMed: 8842708] http://dx.doi.org/10.1093/glycob/6.4.439

InterPro 23.1