EBI Databases InterPro	Search Open in usermanual InterPro:
Jump to: InterProScan Databases Documentation FTP site Help Click on the icon for context sensitive help from the user manual. Advanced search

InterPro: IPR007867 Glucose-methanol-choline oxidoreductase, C-terminal

Protein matches Help

UniProtKB

Matches:

2913 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007867 GMC_OxRtase_C

Type

Domain

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05199	GMC_oxred_C	2913
Signatures in BioMart

InterPro Relationships Help

Found in

IPR011533 Choline dehydrogenase
IPR012132 Glucose-methanol-choline oxidoreductase
IPR012400 Long-chain fatty alcohol dehydrogenase

GO Term annotation Help

Function

GO:0016614 oxidoreductase activity, acting on CH-OH group of donors

InterPro annotation

Entry Details in BioMart

Abstract

The glucose-methanol-choline (GMC) oxidoreductases are FAD flavoproteins oxidoreductases [1, 2]. These enzymes include a variety of proteins; choline dehydrogenase (CHD), methanol oxidase (MOX) and cellobiose dehydrogenase (EC:1.1.99.18) [3] which share a number of regions of sequence similarities. The function of this C-terminal conserved domain is not yet known.

Structural links Help

PDB - click here

SCOP: c.3.1.2 , d.16.1.1

CATH: 3.30.560.10 , 3.50.50.60

Database links Help

Enzyme: EC:1.1.99.1

PANDIT: PF05199

Blocks: IPB007867

Taxonomic coverage Help

Overlapping InterPro entries Help

IPR007867

Numbers of overlapping proteins

Average numbers of overlapping amino acids

Example proteins Help

P12676 Cholesterol oxidase

P18173 Glucose dehydrogenase [acceptor]

Q8BJ64 Choline dehydrogenase, mitochondrial

Q8NE62 Choline dehydrogenase, mitochondrial

Q9S746 Protein HOTHEAD

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR006311	Twin-arginine translocation pathway, signal sequence
IPR000172	Glucose-methanol-choline oxidoreductase, N-terminal
IPR007867	Glucose-methanol-choline oxidoreductase, C-terminal
IPR011533	Choline dehydrogenase
IPR017909	Twin arginine translocation signal, Tat
IPR012132	Glucose-methanol-choline oxidoreductase
	SWISS-MODEL
	PDB Chain
	ModBase
	SCOP Domain
	CATH Domain

Publications Open in usermanual
1.	Cavener DR. GMC oxidoreductases. A newly defined family of homologous proteins with diverse catalytic activities. J. Mol. Biol. 223 811-4 1992 [PubMed: 1542121] http://dx.doi.org/10.1016/0022-2836(92)90992-S
2.	Li J, Vrielink A, Brick P, Blow DM. Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry 32 11507-15 1993 [PubMed: 8218217] http://dx.doi.org/10.1021/bi00094a006
3.	Henriksson G, Johansson G, Pettersson G. A critical review of cellobiose dehydrogenases. J. Biotechnol. 78 93-113 2000 [PubMed: 10725534] http://dx.doi.org/10.1016/S0168-1656(00)00206-6

Additional Reading Open in usermanual
	Lario PI, Sampson N, Vrielink A. Sub-atomic resolution crystal structure of cholesterol oxidase: what atomic resolution crystallography reveals about enzyme mechanism and the role of the FAD cofactor in redox activity. J. Mol. Biol. 326 2003 1635-50 [PubMed: 12595270] http://dx.doi.org/10.1016/S0022-2836(03)00054-8
	Lyubimov AY, Heard K, Tang H, Sampson NS, Vrielink A. Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase. Protein Sci. 16 2007 2647-56 [PubMed: 18029419] http://dx.doi.org/10.1110/ps.073168207
	Lario PI, Vrielink A. Atomic resolution density maps reveal secondary structure dependent differences in electronic distribution. J. Am. Chem. Soc. 125 2003 12787-94 [PubMed: 14558826] http://dx.doi.org/10.1021/ja0289954
	Lyubimov AY, Lario PI, Moustafa I, Vrielink A. Atomic resolution crystallography reveals how changes in pH shape the protein microenvironment. Nat. Chem. Biol. 2 2006 259-64 [PubMed: 16604066] http://dx.doi.org/10.1038/nchembio784
	Chen L, Lyubimov AY, Brammer L, Vrielink A, Sampson NS. The binding and release of oxygen and hydrogen peroxide are directed by a hydrophobic tunnel in cholesterol oxidase. Biochemistry 47 2008 5368-77 [PubMed: 18410129] http://dx.doi.org/10.1021/bi800228w

InterPro 23.1