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InterPro: IPR007857 Skb1 methyltransferase

Protein matches Help

UniProtKB

Matches:

164 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007857 Skb1_MeTrfase

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05185	PRMT5	162
PIRSF	PIRSF015894	Skb1_MeTrfase	140
PANTHER	PTHR10738	Skb1_mtfrase	156
Signatures in BioMart

GO Term annotation Help

Function

GO:0008168 methyltransferase activity

Component

GO:0005737 cytoplasm

InterPro annotation

Entry Details in BioMart

Abstract

The human homologue of Saccharomyces cerevisiae Skb1 (Shk1 kinase-binding protein 1) is a protein methyltransferase [1]. These proteins seem to play a role in Jak signalling.

Database links Help

Enzyme: EC:2.1.1.125

PANDIT: PF05185

Blocks: IPB007857

Taxonomic coverage Help

Example proteins Help

O14744 Protein arginine N-methyltransferase 5

P38274 Protein arginine N-methyltransferase HSL7

P46580 Protein arginine N-methyltransferase 5

Q8CIG8 Protein arginine N-methyltransferase 5

Q9U6Y9 Protein arginine N-methyltransferase 5

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007857	Skb1 methyltransferase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Pollack BP, Kotenko SV, He W, Izotova LS, Barnoski BL, Pestka S. The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase activity. J. Biol. Chem. 274 31531-42 1999 [PubMed: 10531356] http://dx.doi.org/10.1074/jbc.274.44.31531

Additional Reading Open in usermanual
	Rho J, Choi S, Seong YR, Cho WK, Kim SH, Im DS. Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family. J. Biol. Chem. 276 2001 11393-401 [PubMed: 11152681] http://dx.doi.org/10.1074/jbc.M008660200
	Gilbreth M, Yang P, Wang D, Frost J, Polverino A, Cobb MH, Marcus S. The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proc. Natl. Acad. Sci. U.S.A. 93 1996 13802-7 [PubMed: 8943016] http://dx.doi.org/10.1073/pnas.93.24.13802
	Gilbreth M, Yang P, Bartholomeusz G, Pimental RA, Kansra S, Gadiraju R, Marcus S. Negative regulation of mitosis in fission yeast by the shk1 interacting protein skb1 and its human homolog, Skb1Hs. Proc. Natl. Acad. Sci. U.S.A. 95 1998 14781-6 [PubMed: 9843966] http://dx.doi.org/10.1073/pnas.95.25.14781

InterPro 23.1