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InterPro: IPR007781 Alpha-N-acetylglucosaminidase

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UniProtKB

Matches:

151 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
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Accession

IPR007781 GlcNAc_a

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05089	NAGLU	151
PANTHER	PTHR12872	NAGLU	149
Signatures in BioMart

InterPro annotation

Entry Details in BioMart

Abstract

Alpha-N-acetylglucosaminidase is a lysosomal enzyme required for the stepwise degradation of heparan sulphate [1]. Mutations on the alpha-N-acetylglucosaminidase (NAGLU) gene can lead to Mucopolysaccharidosis type IIIB (MPS IIIB; or Sanfilippo syndrome type B) characterised by neurological dysfunction but relatively mild somatic manifestations [2].

Database links Help

PANDIT: PF05089

Taxonomic coverage Help

Example proteins Help

P54802 Alpha-N-acetylglucosaminidase

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Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007781	Alpha-N-acetylglucosaminidase
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Li HH, Yu WH, Rozengurt N, Zhao HZ, Lyons KM, Anagnostaras S, Fanselow MS, Suzuki K, Vanier MT, Neufeld EF. Mouse model of Sanfilippo syndrome type B produced by targeted disruption of the gene encoding alpha-N-acetylglucosaminidase. Proc. Natl. Acad. Sci. U.S.A. 96 14505-10 1999 [PubMed: 10588735] http://dx.doi.org/10.1073/pnas.96.25.14505
2.	Villani GR, Follenzi A, Vanacore B, Di Domenico C, Naldini L, Di Natale P. Correction of mucopolysaccharidosis type IIIb fibroblasts by lentiviral vector-mediated gene transfer. Biochem. J. 364 747-53 2002 [PubMed: 12049639] http://dx.doi.org/10.1042/BJ20011872

InterPro 23.1