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InterPro: IPR007754 N-acetylglucosaminyltransferase II

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UniProtKB

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81 proteins

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Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
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Architectures
Accession List
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Accession

IPR007754 GlcNAc_II

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF05060	MGAT2	81
PANTHER	PTHR12871	MGAT2	78
Signatures in BioMart

GO Term annotation Help

Process

GO:0009312 oligosaccharide biosynthetic process

Function

GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity

Component

GO:0005795 Golgi stack
GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

N-acetylglucosaminyltransferase II (EC:2.4.1.143) is a Golgi resident enzyme that catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides [1]. Mutations in the MGAT2 gene lead to a congenital disorder of glycosylation (CDG IIa). CDG IIa patients have an increased bleeding tendency, unrelated to coagulation factors [2].

Synonym(s): UDP-N-acetyl-D-glucosamine:alpha-6-D-mannoside beta-1,2-N- acetylglucosaminyltransferase II, GnT II/MGAT2.

Database links Help

Enzyme: EC:2.4.1.143

PANDIT: PF05060

Blocks: IPB007754

CluSTr: ALLvsALL:147778:41.3

Taxonomic coverage Help

Example proteins Help

O19071 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Q10469 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Q921V5 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007754	N-acetylglucosaminyltransferase II
	ModBase

Publications Open in usermanual
1.	D'Agostaro GA, Zingoni A, Moritz RL, Simpson RJ, Schachter H, Bendiak B. Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II. J. Biol. Chem. 270 15211-21 1995 [PubMed: 7797505] http://dx.doi.org/10.1074/jbc.270.25.15211
2.	Van Geet C, Jaeken J, Freson K, Lenaerts T, Arnout J, Vermylen J, Hoylaerts MF. Congenital disorders of glycosylation type Ia and IIa are associated with different primary haemostatic complications. J. Inherit. Metab. Dis. 24 477-92 2001 [PubMed: 11596651] http://dx.doi.org/10.1023/A:1010581613821

InterPro 23.1