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InterPro: IPR007680 Mycobacterial cell wall arabinan synthesis protein

Protein matches Help

UniProtKB

Matches:

179 proteins

Overview:	sorted by AC,	sorted by name,	of known structure,	proteins with splice variants
Detailed:	sorted by AC,	sorted by name,	of known structure	proteins with splice variants
Table:	For all matching proteins,	of known structure
Architectures
Accession List
Matches in BioMart

Accession

IPR007680 Mycobac_arabinan_synth

Type

Family

Signatures Help

Database	ID	Name	Proteins
Pfam	PF04602	Arabinose_trans	179
Signatures in BioMart

GO Term annotation Help

Process

GO:0009252 peptidoglycan biosynthetic process

Function

GO:0016763 transferase activity, transferring pentosyl groups

Component

GO:0016021 integral to membrane

InterPro annotation

Entry Details in BioMart

Abstract

Arabinosyltransferase is involved in arabinogalactan (AG) biosynthesis pathway in mycobacteria. AG is a component of the macromolecular assembly of the mycolyl-AG-peptidoglycan complex of the cell wall. This enzyme has important clinical applications as it is believed to be the target of the antimycobacterial drug Ethambutol [1].

Database links Help

Enzyme: EC:2.4.2

PANDIT: PF04602

Blocks: IPB007680

Pfam Clan: CL0111.7

Taxonomic coverage Help

Example proteins Help

P0A560 Probable arabinosyltransferase A

More proteins

Example Proteins Key

InterPro entry accession number/name and structure databases		Colour code
IPR007680	Mycobacterial cell wall arabinan synthesis protein
	SWISS-MODEL
	ModBase

Publications Open in usermanual
1.	Belanger AE, Besra GS, Ford ME, Mikusova K, Belisle JT, Brennan PJ, Inamine JM. The embAB genes of Mycobacterium avium encode an arabinosyl transferase involved in cell wall arabinan biosynthesis that is the target for the antimycobacterial drug ethambutol. Proc. Natl. Acad. Sci. U.S.A. 93 11919-24 1996 [PubMed: 8876238] http://dx.doi.org/10.1073/pnas.93.21.11919

InterPro 23.1